CURRICULUM
VITAE
Imaging Research Laboratories.
University Education:
Ph.D. 1986-1992, University of
Toronto, Dept. of Medical Biophysics.
Thesis: “A TDI-CCD
System for Slot-Scanned Digital Radiography and computed Tomography”
Supervisor: Dr. A. Fenster (Medical Biophysics)
M.Sc.
1984-1986,
University of Toronto, Dept. of Astronomy.
Thesis: “A Study of Optical Fibers for Astronomical Instrumentation”
Supervisor: Dr. Stefan Mochnacki (Astronomy)
Professional Experience:
July, 1993- Assistant
Professor, Dept. of Diagnostic Radiology and Nuclear Medicine,
June, 1997 University
of Western Ontario
Memberships in Professional Organizations:
Society of Photo-Optical Instrumentation Engineers
International
Society for Magnetic Resonance in Medicine
Canadian Organization
of Medical Physicists
American Institute
of Ultrasound in Medicine
Research Grants-Current:
MRC 1996-1999 $42,231 per annum
“Image-guided therapy for intracranial aneurysms using 3-D
computed tomography,” D.W. Holdsworth, A.J. Fox
MRC 1997-2000 $83,412 per annum
“Development of new vascular ultrasound imaging systems,”
A. Fenster, D.W. Holdsworth, and R.N. Rankin.
MRC 1997-2000 $79,808 per annum
“Integrated vascular MR imaging,” B.K. Rutt, D.W. Holdsworth,
D. Steinman, M. Drangova, and D.H. Lee
Salary
Awards – Current
Heart and Stroke Foundation 1997-2002 $44,660
Patents:
1. “Computer-controlled pump for physiological
flow simulation, British Patent No. 9104097.2 US Patent #5284423 (1993) D.W.
Holdsworth, M. Drangova, D. Rickey, A. Fenster.
2. “Pulse-injector for quantitative angiographic
blood-flow measurements,” British Patent No. 9225014.1 (Nov. 30, 1992), US Patent
#5485331 (Jan. 23, 1996) D.W. Holdsworth, M. Drangova, A. Fenster.
Publications
Cardinal, H.N., Holdsworth, D.W., Drangova, M., Hobbs,
B.B. and Fenster, A., “Experimental and theoretical x-ray imaging performance
comparison of iodine and lanthanide contrast agents,” Med. Phys. 20,
15-31 (1993).
Frayne, R., Gowman, L.M., Rickey, D.W., Holdsworth,
D.W., Picot, P., Drangova, M., Caldwell, C.B., Fenster, A. and Rutt, B.K., “A
geometrically accurate vascular phantom for comparative studies of x-ray, ultrasound
and magnetic resonance vascular imaging: Construction and geometrical verification,”
Med. Phys. 20, 415-425 (1993).
Holdsworth, D.W., Drangova, M., Fenster,
A., “A high-resolution quantitative volume CT scanner,” Med. Phys. 20,
449-462 (1993).
Drangova, M., Holdsworth, D.W., Boyd, C.J., Dunmore,
P.J., Roach, M.R. and Fenster, A., “Elasticity and geometry measurements of
vascular specimens using a high-resolution laboratory CT scanner,” Physiol.
Meas. 14, 277-290 (1993).
Drangova, M., Holdsworth, D.W., Picot, P.A., Schulenburg,
K. and Fenster, A., “A modified x-ray image intensifier with continuously variable
field of view for high-resolution imaging,” Med. Phys. 20, 1653-1660
(1993).
Moreau, M., Holdsworth, D.W., and Fenster, A., “Dual-energy
x-ray imaging technique for in vitro tissue composition measurement,”
Med. Phys., 21, 1807-1815 (1994).
Frayne, R., Holdsworth, D.W., Smith, R.F., Kasrai,
R., Larsen, Jan P.T., and Rutt, B.K., “Turbine flow sensor for volume-flow rate
verification in MR,” Mag. Reson. Med. 32, 410-417 (1994).
Lauzon, M., Holdsworth, D.W., Frayne, R., and Rutt,
B.K., “Effects of waveform variability in gated MRI: A theoretical understanding,”
J Mag. Reson. Imag., 4, 853-867 (1994).
Eliasziw, M., Smith, R.F., Singh, N., Holdsworth,
D.W., Fox, A.J., and Barnett, H.J.M, “Further comments on the measurement of
carotid stenosis from angiograms,” Stroke, 25, 2445-2449 (1994).
Smith, R.F., Fox, A.J., Rankin, R.N., Rutt, B.K., and Holdsworth,
D.W., “Geometric characterization of stenosed human carotid arteries,” Academic
Radiology 3, 898-911 (1996).
Moreau, M., Holdsworth, D.W., and Fenster, A., “X-ray
imaging technique for in vitro tissue composition measurements using
saline/iodine displacement: Technique optimization,” Med. Phys. 24, 37-49
(1997).
Moreau, M., Dunmore-Buyze, P.J., Holdsworth, D.W.,
and Fenster, A., “X-ray imaging technique for in vitro tissue composition
measurements using saline/iodine displacement: Experimental verification,” Med.
Phys. 24, 351-360 (1997).
Dabrowski, W., Dunmore-Buyze, J., Rankin, R.N., Holdsworth,
D.W., and Fenster, A., “A real vessel phantom for imaging experimentation,”
Med. Phys. 24, 687-693 (1997).
Fahrig, R., Moreau, M., and Holdsworth, D.W., “3-D
CT reconstruction using a C-arm mounted XRII: Correction of image intensifier
distortion,” Med. Phys., 24, 1097-1106 (1997).
Fahrig, R., Holdsworth, D.W., Fox, A.J., and Lownie,
S., “Use of a C-arm system to generate true 3-D computed rotational angiograms:
Preliminary In Vitro and In Vivo results,” AJNR, Am. J. Neuroradiol 18,
1507-1514 (1997).
Book Chapters:
Finlay, J.B, Hurtig, M., Ng, A.,
Liggins, A.B., Shemerluk, R., Lorantfy, C., Lysynski, B. and Holdsworth,
D.W., “Study of the pin-bone interface in fracture fixation: High tech-low tech,”
in Experimental Mechanics, E.G. Little ed. (Elsevier Science Publishers,
Amsterdam, 1992).
Invited Presentations:
Holdsworth, D.W.,
Drangova, M., and Fenster, A., “A high-resolution volume CT scanner for biomedical
research,” NASA Ames Research Center, Moffett Field CA, Feb. 11, (1993).
Holdsworth, D.W.
“Vascular Anatomy and Blood Flow: CT, MR, and Ultrasound Investigations” Siemens
Medical Systems, Erlangen, Germany, Dec. 7, (1993).
Holdsworth, D.W.,
Smith, R.F., Rutt, B.K., Fox, A.J., Rankin, R.N., “In vitro validation
of Doppler ultrasound, MRA, and DSA Techniques,” NASCET Eastern Regional meeting,
New York NY, June 13 (1994).
Holdsworth, D.W.,
Drangova, M., and Fenster, A., “A high-resolution volume CT scanner for bone
densitometry,” Eli Lilly, Indianopolis Indiana, May. 12, (1995).
Holdsworth, D.W.,
“New imaging techniques for in vitro measurements of the mechanical properties
and composition of vascular tissue,” Guest Lecture at the Cleveland Clinic Foundation,
Cleveland OH, May 12 (1995).
Holdsworth, D.W.,
“Quantification of blood flow and vessel geometry using CT, MR, and ultrasound,”
Invited lecture at Siemens Corporate Research, Princeton, N.J. May 3, (1996).
Holdsworth, D.W.,
“High-resolution three-dimensional computed tomography,” AAPM Annual Meeting,
Philadelphia, PA. July 23, (1996).
Holdsworth, D.W.,
Fahrig, R., and Fox, A.J., “High-resolution 3-D CT angiography from multiple
2-D projections,” VIII International Workshop: Advances in 3-D Vascular Imaging,
Rome Oct. 16-19 (1996).
Holdsworth, D.W., Smith,
R.F., Fahrig, R., Rutt, B.K., and Fox, A.j., “Anthropomorphic vascular models
for in vitro evaluation of MRA and CT, “ VIII International Workshop:
Advances in 3-D Vascular Imaging, Rome Oct. 16-19 (1996).
Holdsworth, D.W.,
Fahrig, R., and Fox, A.J., “Three-dimensional computed rotational angiography,”
Institute for Medical Physics, Friedrich-Alexander University, Erlangen, Germany
Oct. 25 (1996).
Ethier, C.R., Moore, J.A., Steinman,
D.A., and Holdsworth, D.W., “Construction of vascular models from MRI:
accuracy assessment based on flow simulations in a carotid bifurcation model,”
Presented at the 1st International Interdisciplinary Conference on
Cardiovascular Medicine, Surgery, Science, and Mechanics, Washington D.C., June
(1997).