Osteoporosis:
Osteoporosis, or "porous bone," is a disease characterized by low bone
mass and the gradual deterioration of bone. The disease leads to fragile bones and possible fractures, typically of the wrist, hip or spine. Osteoporosis often progresses unnoticed and without pain until a debilitating fracture occurs. Available therapies prevent further bone loss rather than stimulating the formation of new bone.

Millions are either diagnosed or at risk for osteoporosis; 80% of them are women. The disease strikes all ethnic groups, and while generally affecting older adults, can occur at any age.

In addition to gender and age, other risk factors include:

• a thin or small-frame body type
• a family history of the disease
• postmenopausal
• low level of calcium in the diet
• inactivity
• cigarette smoking
• excessive use of alcohol

Osteoporosis can be detected by a Bone Mineral (BMD) test, which measures bone mass at various points on the body. Repeated BMD measurements can determine the rate of bone loss, indicate the risk of fracture and monitor the effects of treatment.

How New Drugs Are Tested

In compliance with government laws and regulations, a new investigational drug must undergo a series of pre-clinical and clinical research studies to prove that it is both effective for the designated medical condition and safe for use. After all phases of research are completed, a new drug application is submitted to the appropriate regulatory agency for review. If that agency determines the drug or treatment is safe and effective, it grants marketing approval.

Clinical Research Studies

A clinical research study (or research trial) is a supervised evaluation of a medication to determine its safety and effectiveness in treating osteoporosis. Individuals enrolled in these trials receive study medications, and doctors evaluate their responses under carefully controlled conditions.

If you are interested in participating in a clinical trial and want more information, call 646-6100 Ext.64742

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Last Updated: Tuesday, 23-Feb-2010 04:08:10 EST