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It’s been another year of transformational research at Lawson Health Research Institute. Our teams have published groundbreaking findings and launched new studies that will have a profound impact on patient care.

The following are 12 highlights of research and innovation from across London Health Sciences Centre (LHSC) and St. Joseph’s Health Care London (St. Joseph’s). From trialing new cancer treatments to advancing understanding of mental health, our research teams have achieved a number of important milestones. 

1. New study suggests blood plasma proteins hold answers to better understanding long COVID

Lawson researchers continued to advance understanding of COVID-19 this past year. In one study, researchers found that unique patterns in blood plasma proteins of patients with suspected long COVID could act as a drug target to improve patient outcomes. Read more.

2. New study finds exercise, cognitive training combo boosts mental sharpness in seniors

A study from Lawson and Western University found that a combination of computerized cognitive training and aerobic-resistance exercises can improve functions like memory, attention, recognition and orientation in older adults with mild cognitive impairment. The results suggest a new way to address declining mental sharpness in older adults. Read more.

3. $7.55 million in funding to take LHSC-developed technology global

Technology to diagnose rare genetic disorders developed by researchers at Lawson and LHSC will be going global thanks to $7.55 million in funding from Genome Canada grant and Illumina Inc. The new artificial intelligence-led technology could allow rare diseases to be diagnosed with a simple blood test. Read more.

4. Fecal transplants show promise in improving melanoma treatment

Fecal microbiota transplants (FMT) from healthy donors are safe and could improve response to immunotherapy in patients with advanced melanoma, according to results from a world-first multi-centre clinical trial led by Lawson researchers. Read more.

5. New study shows technology could play an important role in mental health support

A team of Lawson researchers found that the use of ‘smart home’ technology like touch screen devices, activity trackers, weigh scales and medication dispensers may lead to better outcomes for those living with both mental health and physical disorders. The study found that participants using the technology started logging more exercise, making healthier food choices and not missing medication doses. Read more.

6. Canadian children’s hospital visits for suicidal thoughts, self-poisoning and self-harm up during pandemic, study finds

A national study with Lawson researchers found that during the first two years of the COVID-19 pandemic, adolescent emergency department (ED) visits and hospitalizations for suicidal thoughts, self-harm and self-poisoning increased across Canada, with the greatest increase occurring among adolescent girls. Read more.

7. St. Joseph’s to become Canada’s first centre of excellence in molecular imaging and theranostics

A partnership between Lawson, St. Joseph’s Health Care London and GE HealthCare will create Canada’s first centre of excellence in molecular imaging and theranostics at St. Joseph’s. The centre will focus on using precision diagnostic imaging and targeted therapy to advance personalized treatment of cancer and other diseases. Read more.

8. Researchers investigate a new method of sedation for paediatric patients

Intravenous sedatives are normally used to sedate critically ill children. However, they can contribute to a complication called delirium, which includes symptoms of confusion, disorientation, agitation, excessive drowsiness and poor attention. To improve outcomes, scientists at Children’s Health Research Institute (a program of Lawson), Sunnybrook Research Institute and The Hospital for Sick Children (SickKids) are collaborating on a pilot study to understand whether inhaled sedation could be a better alternative to keep critically ill children sedated and comfortable. Read more.

9. New robotic 3D ultrasound may improve accuracy of liver cancer ablation therapy

A technique that turns a normal ultrasound into a 3D image is showing promise in making thermal ablation for liver cancer treatment more accurate in a study from Lawson and Western University. Thermal ablation – using heat to destroy a cancerous tumour – can have fewer complications and a shorter recovery time than surgery. Read more.

10. Assessing neurofeedback in stroke survivors

Functional near-infrared spectroscopy (fNIRS) is used to detect changes in brain oxygen levels using light, but more recently it has also been used to develop brain-computer interfaces – allowing patients with brain injuries to control a device with their thoughts. Researchers at Lawson launched a new study to assess whether fNIRS can be used to improve patient outcomes during stroke rehabilitation. Read more.

11. Specific type of inflammation may be linked to risk of colorectal cancer

A preclinical study found that a specific type of inflammation may be linked to an increased risk of colorectal cancer. Previously, the degree of inflammation caused by illnesses like colitis, Crohn’s disease and other forms of inflammatory bowel disease were shown to be an important indicator of the development of colorectal cancer. However, this new study found the type of inflammation, rather than the severity and duration, may be more important in determining cancer risk. Read more.

12. New study examining if probiotics can improve outcomes in knee replacement surgeries

Lawson researchers launched a study to assess whether daily probiotics can improve outcomes in patients undergoing a total knee replacement surgery. Of the more than 70,000 knee replacement surgeries in Canada each year, nearly 10 per cent of patients experience complications. With patients who are considered healthy likely to have better outcomes, the research team is interested in improving the gut microbiome as a way to support patients’ overall health. Read more.

 

In a new study from Lawson Health Research Institute and Western University, researchers partnered with youth receiving care at the First Episode Mood and Anxiety Program (FEMAP) at London Health Sciences Centre (LHSC) to better understand personal perspectives on care and treatment outcomes. The study found that patients experienced lasting improvements in managing their symptoms and improvements in academics, work performance and relationships, and they reported that these benefits involved being empowered by feelings of self-acceptance.

The study included 22 patients from FEMAP, a novel outpatient mental health program at LHSC that provides treatment to ‘emerging adults,’ ages 16 to 25, with emotional concerns that fall into the categories of mood and anxiety symptoms. Treatment at FEMAP takes a patient-centred approach and the research involved looking at what is meaningful and valuable to patients during their care journey.

“The transition from adolescence to adulthood is challenging. FEMAP employs an innovative model of care tailored to the needs of this complex population,” said Dr. Elizabeth Osuch, a clinician-scientist at Lawson, associate professor at Western University’s Schulich School of Medicine & Dentistry and medical director at FEMAP. “By engaging patients in a reflection of their experience, we can learn how effective the program is from the patient perspective.”

Participants shared their experiences through open-ended interviews with Dr. Osuch’s research team. Interview transcripts were collected and analyzed to determine common themes around treatment and outcomes. These themes were then presented back to the research participants for validation.

The study found that treatment led to development of coping strategies to better manage symptoms. Research participants credited these strategies for better functioning in academics, careers and personal relationships. Challenges in these areas are common among emerging adults and are often stressors that lead to youth seeking mental health care.

Participants characterized their treatment at FEMAP as an important investment in their mental health and wellbeing, and credited a collaborative partnership with their care provider for keeping them engaged in treatment. They appreciated the ease of accessing treatment at FEMAP where they could receive care from a psychiatrist, social worker, addictions counsellor, family counsellor and a psychologist, depending on their needs.

The research found that the complexities of treatment were initially frustrating to patients as they were seeking an “easy fix” to their mental health concerns, but they ultimately appreciated that mental health recovery is a journey. They valued that care providers partnered with them to set long-term treatment goals, choose the best treatment options and provide support both during and between appointments.

“Patients may prefer FEMAP over other mental health services because the care is tailored to emerging adults,” said Justin Arcaro, first author on the study and a former MSc candidate at Schulich Medicine & Dentistry and research associate at FEMAP. “There’s an important balance between recognizing emerging adults’ personal autonomy and their need for comprehensive support.”

Study results demonstrated that through treatment at FEMAP, patients realized they are not alone in their mental health journey which led to improved self-acceptance and self-compassion. Participants reported feeling empowered to create meaningful changes in their lives.

Participants also discussed the decision to seek mental health care in the first place. Many struggled with the decision of whether or not treatment was needed. “This shows a need for targeted campaigns to help emerging adults distinguish between normative feelings and those that indicate a need for help,” said Dr. Osuch.

This study also aligns with other research projects at FEMAP that suggest a need for targeted education campaigns about mental health care as a process with solutions that are not necessarily quick or easy. The research team highlights the importance of these findings in informing future funding decisions and policy around mental health care for emerging adults. The findings emphasize the need for quick engagement with a trusted care provider and an integrated treatment team that can partner with patients to support them while enhancing independent growth and self-acceptance.

The study, “Emerging adults’ evaluation of their treatment in an outpatient mood and anxiety disorders program,” is published in Emerging Adulthood.

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Above: Dr. Elizabeth Osuch and Justin Arcaro