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History
Each hospital’s research mission has a rich history. At both hospital organizations, leaders recognized opportunities to leverage in-house experts to conduct research and improve care. However, they also recognized the challenge in supporting these activities without dedicated space and resources.
Through great foresight, our hospitals founded the official research institutes that serve as Lawson's foundation:
- 1983: Supported by Sister Mary Doyle, former Executive Director of St. Joseph's, the Sisters of St. Joseph's establish the hospital's official research institute. LHSC and Upjohn jointly open the Victoria Upjohn Clinical Research Unit at South Street Hospital (formerly Victoria Hospital), focusing on Phase I-III clinical trials.
- 1987: The St. Joseph's research institute is named the Lawson Research Institute (LRI) in honour of London businessman and philanthropist Colonel Tom Lawson and his wife, Miggsie Lawson - close friends of Sister Mary Doyle and major supporters of the research mission.
- 1990: Victoria Hospital takes over the operation of the clinical research unit at South Street, renaming it the Victoria Clinical Trials Centre.
- 1997: The Victoria Clinical Trials Centre is renamed London Health Sciences Centre Research Inc. and becomes a fully incorporated research institute overseeing all hospital-based research within London Health Sciences Centre sites: Victoria Hospital, University Hospital and South Street Hospital.
- 2000: LRI and LHSCRI merge to form a joint venture: Lawson Health Research Institute.
- 2014: Lawson Research Institute (re-)launches as the hospital-based research arm of St. Joseph's with the goal of transforming imagination to innovation to impact; and as LHSCRI is also embedded into LHSC.
Today, partnerships remain strong, allowing researchers to move seamlessly between hospital locations and Western University.
Milestones
Since forming in 2000, Lawson has pioneered breakthroughs across various disciplines of health research and reached several institutional milestones.
- 2019: Lawson led research team is the first in the world to develop a new imaging tool, showed that MRI can be used to measure how the heart uses oxygen.
- 2019: New studies from Lawson and Western University found for the first time that HIV can be transmitted through the sharing of equipment used to prepare drugs before injection and that a simple intervention can destroy the HIV virus, preventing that transmission.
- 2019: In the first genomic analysis of head and neck cancer by smoking status, researchers at Lawson, in collaboration with researchers at the Ontario Institute for Cancer Research and UCLA Cancer Centre, carried out a comprehensive genetic analysis of HPV-negative tumours to better understand the link between smoking and cancer recovery.
- 2019: Lawson scientists develop molecular diagnostic tool to analyze epigenetic patterns, facilitating diagnosis of rare, unknown hereditary disorders. London Health Sciences Centre is the first site in the world to offer this type of testing.
- 2018: Research shows high-dose radiation can improve survival in patients with cancer that has spread to give or less sites. The SABR-COMET study was the first randomized phase II clinical trial of its kind.
- 2018: An international collaborative study between Lawson Health Research Institute, Memorial Sloan Kettering Cancer Center, the Royal Marsden and Epic Sciences is one of the first to demonstrate that a blood test can predict how patients with advanced prostate cancer will respond to specific treatments, leading to improved survival.
- 2018: In collaborative study between Lawson and Stanford University, scientists develop and test a new synthetic surfactant that could lead to improved treatments for lung disease and injury.
- 2018: Scientists use brain MRI to develop first ever method examining young people before they become ill to reliably identify who will develop acute psychosis and who will not.
- 2018: Research team develops clinically-validated, open-source 3D printed stethoscope for areas with limited access to medical supplies.
- 2018: Lawson opens Clinical Research and Chronic Disease Centre (CRCDC) at St. Joseph’s Hospital to tackle chronic disease and improve patient care.
- 2018: Lawson researchers receive $4.4 million to study personalized medicine at LHSC, examining the value of prescribing treatments based on a patient’s genetics.
- 2017: In one of the largest microbiota studies conducted in humans, researchers at Western University, Lawson Health Research Institute and Tianyi Health Science Institute in Zhenjiang, Jiangsu, China have shown a potential link between healthy aging and a healthy gut.
- 2017: Lawson researchers develop transition program to help young adults with type 1 diabetes move from paediatric to adult care.
- 2017: Innovative study brings next-generation genome sequencing to London cancer patients, contributing to province-wide database of genomic and clinical data.
- 2017: Technology developed at Western University and Lawson Health Research Institute can provide a new window into whether or not patients are responding to treatment for advanced ovarian cancer.
- 2017: Dr. Alan Getgood and his team at Western University and Lawson Health Research Institute are the first in Canada to participate in an investigative trial to determine the safety and efficacy of using a patient’s own cartilage cells to repair knee cartilage injuries.
- 2016: Lawson Researchers at Parkwood Institute are the first in Canada to develop clinical practice guidelines for managing neuropathic pain with patients who have experienced a spinal cord injury.
- 2016: Researchers at Lawson are the first in Canada to use a Prostate Specific Membrane Antigen (PSMA) probe in Positron Emissions Tomography (PET) scans to provide improved and highly specific images used for better diagnosis and management of prostate cancer.
- 2015: Lawson scientists, in collaboration with Ceresensa Inc., produce novel PET-transparent MRI head coil, a world first in imaging technology
- 2015: Lawson announces partnership with STEMCELL Technologies for commercialization of tools for Parkinson’s disease research
- 2015: Novare Pharmaceuticals and Lawson announce issuance of a U.S. patent for the composition-of-matter and use of RHAMM-binding peptides with a wide range of potential therapeutic uses. The patent also has claims for the diagnosis and prognosis of cancer, and for prescribing a course of treatment for the diagnosed cancer.
- 2014: Lawson announces licensing agreement with Yabao Pharmaceutical Group in China to develop and test a new life-saving drug to treat sepsis
- 2014: Lawson researchers are part of a Canadian team who have developed a way to produce a key medical isotope, technetium-99m (Tc-99m), using hospital based cyclotrons
- 2013: The Institute for Clinical Evaluative Sciences (ICES) Western opens at Lawson
- 2012: Lawson installs Canada's first PET/MRI at St. Joseph's Hospital
- 2011: Lindros Legacy Research Building officially opens at University Hospital
- 2010: Lawson opens the Cyclotron and PET Radiochemistry facility at St. Joseph's Hospital
- 2009: Lawson receives a record $7 million donation to support the Canadian Research & Development Centre for Probiotics
- 2008: Lawson establishes an experimental anti-thrombolitic clinic to calculate personalized dosage of drugs based on a patient's genetics
- 2007: The first totally endoscopic closed-chest robotic coronary artery bypass surgery on a patient's beating heart is performed at University Hospital
- 2006: Lawson opens the Aging, Rehabilitation & Geriatric Care Research Centre, the first centre of its kind in Canada, at Parkwood Institute
- 2005: Lawson creates the first Ontario Cardiac Rehabilitation Registry
- 2004: Lawson scientists release a three-year study on the effects of the Walkerton water disaster
- 2003: Lawson opens the Victoria Research Laboratories at Victoria Hospital, the first collaboration of its kind in Canada bringing together research from cancer, children's health and vascular biology
- 2002: Lawson installs the first Positron Emission Tomography and Computer Tomography (PET/CT) scanner in Canada at St. Joseph's Hospital
- 2001: St. Joseph's is one of five sites in the world piloting the Diabetes Electronic Management Systems
Improving mental health treatments for stroke patients is the focus of a new study
LONDON, ON- Strokes affect approximately 400,000 Canadians each year and can be debilitating. They can negatively affect a person’s cognition and mobility, and severely impact mental health and wellbeing.
A team at Lawson Health Research Institute are looking to improve mental health treatments and resources for patients who have experienced a stroke. The team will recruit 100 stroke patients to assess whether the completion of a guided therapy program can improve mental health and quality of life.
“More than sixty per cent of patients experience depression after stroke,” says Dr. Robert Teasell, Lawson Scientist and Physiatrist at St. Joseph’s Health Care London’s Parkwood Institute. “Having a stroke itself makes people more vulnerable and makes people feel their lives have changed negatively.”
During stroke rehabilitation, patients are typically offered mental health treatments, but the research team say it is post rehabilitation that stroke patients tend to experience worsening depression.
“Publicly funded allied health care services are available at inpatient and outpatient care; however, psychology is often limited across the rehabilitation continuum from acute to community care,” says Dr. Swati Mehta, Lawson Scientist. “We are looking at how we can provide a program that is cost effective to help those who have these barriers to access mental health services.”
“Patients have described to me that they feel like they have been dropped off a cliff because of the lack of resources once their programs have ended,” adds Dr. Teasell.
The study will examine the use of cognitive behavioral therapy (CBT), which is an evidence based psychological intervention that aims to provide people with increased coping ability and self-efficacy. Participants will complete a 10-week guided program with specific targeted lessons, tailored to the needs of those post stroke, delivered virtually through a trained clinician. They will then complete a questionnaire to see if there have been any improvements to self-efficacy and emotional wellbeing.
“We have found this form of therapy (CBT) has been very effective and feasible for spinal cord injury patients with mild traumatic brain injury and we want to see how a modified version could potentially help those with stroke and depression,” says Randy Upper, Clinical Research Associate at Lawson.
If CBT is proven effective through this study, Dr. Mehta hopes it will encourage similar programming that would be available to stroke patients after rehab.
“We are hoping we can connect with community organizations and work with them to implement this program in a service delivery model that would be easily accessible for stroke patients living in the community.”
Recruitment for this study is currently underway, those interested in taking part can email Dr. Swati Mehta at: @email
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Communications & Public Engagement
T: 519-685-8500 ext. 73502
Celine.zadorsky@lhsc.on.ca
Improving recovery and rehabilitation for patients with mental illness
Over 130 hospital-based clinical, administrative and research staff members, persons with lived experience of mental illness, family caregivers, peer and community supporters, and staff from local community mental health agencies attended the 18th Annual Mental Health Research & Innovation Half Day on November 1, 2017. The event provided an opportunity to learn more about mental health research at Parkwood Institute and the Southwest Centre for Forensic Mental Health Care (Southwest Centre), part of the St. Joseph’s Health Care London (St. Joseph’s) family.
“This year’s Mental Health Research and Innovation Half Day was one of the best attended in our history of hosting the event. We had a very diverse and engaged audience with great energy and a lot of enthusiasm,” says Dr. Arlene MacDougall, Director of Research and Innovation for mental health care at St. Joseph’s and Lawson Health Research Institute (Lawson).
Exciting recent projects were showcased though talks highlighting excellence in recovery and rehabilitation research, the theme of this year’s event; poster presentations; the 13th Annual Tony Cerenzia Research Lecture delivered by Dr. Sean Kidd; and interactive workshop sessions.
“We chose ‘recovery and rehabilitation’ as the theme for the event because it is so important in our clinical care and research programs to have this focus. We need to prioritize the development, implementation and evaluation of practices and interventions that foster recovery of the whole person experiencing mental illness, which includes their psychological, social and other needs that go beyond traditional notions of healthcare,” Dr. MacDougall adds.
13th Annual Tony Cerenzia Research Lecture
Guest speaker Dr. Kidd’s talk – “From clinical trials to the clinic: A story about making Cognitive Adaptation Training for schizophrenia more accessible” – focused on how to implement interventions proven in clinical trials. Dr. Kidd is a clinical psychologist, senior scientist and psychology division chief at the Centre for Addiction and Mental Health (CAMH) in Toronto. He is also an associate professor in the Department of Psychiatry at the University of Toronto.
Above: Dr. Sean Kidd's lecture focused on implementing interventions proven in clinical trials.
Workshop Sessions
Following Dr. Kidd’s lecture, attendees had the opportunity to participate in one of six workshops on a variety of topics related to recovery and rehabilitation focused mental health research:
“Implementing Interventions: A facilitated conversation attending to evidence, strategy, and recovery oriented care”
Led by Dr. Sean Kidd
Participants shared successful strategies for implementing novel approaches to care and discussed the challenges involved. They also looked at ways to leverage technology and education materials.
“Spirituality in Mental Health Care: Practically Supporting Recovery and Wellness”
Led by Stephen Yeo, Lawson allied scientist and chaplain, Southwest Centre; and Dr. Clark Heard and Jared Scott, Lawson associate scientists and occupational therapists, Southwest Centre
This workshop focused on the practical application of spirituality within the clinical setting, including the use of labyrinths, which contribute to recovery by promoting spiritual self-care, insight development and personal meaning-making reflection. Attendees had the opportunity to participate in a labyrinth walk and a related spiritual reflection. Read more about the labyrinths at Parkwood Institute and the Southwest Centre or watch the following video featuring highlights from the workshop:
“Indigenous Men’s Health and Wellbeing: Connection with Culture as a Rehabilitation and Recovery Tool”
Led by Bill Hill, social worker, Parkwood Institute and Dr. Vicki Smye, associate professor, director of nursing at Western University
Through the sharing of practitioner experience and Indigenous men’s voices, the workshop focused on understanding the powerful links between connection to culture and mental health and well-being (pictured below).
“Engaging Service Users and their Families in Research”
Led by Dr. Cheryl Forchuk, The Beryl and Richard Ivey Research Chair in Aging, Mental Health, Rehabilitation and Recovery, Lawson; and Deborrah Sherman, executive director, Ontario Peer Development Initiative
Participants in this workshop discussed the benefits of patient and family involvement in mental health research and identified strategies to support patient and family engagement (pictured below).
“Innovation in Mental Health Care: Moving Ideas to Impact”
Led by Kaitlin Saxton, research and innovation facilitator, Parkwood Institute; and Lisa Bitcola, centre manager of projects and operations, Ivey International Centre for Health Innovation
This workshop focused on how innovation relates to research and quality improvement initiatives within St. Joseph’s Mental Health Care facilities. Participants discussed innovative approaches that could be implemented within their own clinical practice, research and quality improvement initiatives (pictured below).
“My Professional Practice: Where's the Research?”
Led by Amanda Thibeault, director, professional practice, St. Joseph’s
In this session, participants discussed how they can incorporate research into their clinical practice (pictured below).