Lawson Research Institute scientists and partners will focus on molecular imaging and theranostics to potentially transform the detection and treatment of neurodegeneration and cancer.

The quest to advance detection and treatment of Alzheimer’s disease and to personalize cancer care has received a major boost, with $7.2 million in funding to Lawson Research Institute (Lawson) of St. Joseph’s Health Care London (St. Joseph’s) for first-of-its kind research.

Lawson scientists will partner with a broad team of researchers at London Health Sciences Centre Research Institute (LHSCRI), McMaster University, University Health Network and BC Cancer on the ground-breaking studies focused on molecular imaging and theranostics as a potential game-changer in detecting and treating neurodegeneration and cancer, particularly prostate, brain and breast cancer.

Principal investigator Ting-Yim Lee, PhD, Lawson’s Director of PET/CT Research, and his team of investigators were awarded $2 million through the Ontario Research Fund – Research Excellence for the study titled “Improving Cancer and Alzheimer’s Disease Diagnosis and Treatment Through Cutting-edge Molecular Imaging and Theranostics”. Co-Principal Investigator is radiation oncologist Dr. Glenn Bauman at LHSCRI.  

Additional funding from private-sector partners and Lawson, as well as from donors through St. Joseph’s Health Care Foundation, brings the total research investment to $7.2 million.  

The research has the potential to offer hope for solutions to some of the most prevalent and pernicious diseases affecting Canadians, explains Lee.  

“Both research projects are the first of their kind in Canada aimed at advancing how we diagnose and treat Alzheimer’s disease and cancer,” he says. “This collaborative funding initiative will also drive innovation in the exciting field of molecular imaging and theranostics at St. Joseph’s, at the heart of which is St. Joseph’s new, high-sensitivity GE HealthCare Omni Legend 2 PET/CT – the first in Canada.”

The studies encompass the following:  

• Alzheimer’s disease: The new PET/CT at St. Joseph’s allows researchers to simultaneously study both blood flow and glucose metabolism in the brain. Both these mechanisms are believed to be contributing factors in the onset of Alzheimer’s. By measuring both at the same time, the research team hopes to uncover early signs that the brain is in trouble and at risk of plaque deposits and toxic proteins that have been linked to the development of Alzheimer’s.
• Cancer: The cancer study will focus on developing theranostic techniques to achieve personalized dosimetry – a method used to determine the exact amount of radiation a patient should receive during treatment, based on their individual characteristics. This maximizes effective treatment while minimizing harm to healthy tissues.

Molecular imaging and theranostics is a rapidly emerging field of medicine that combines ultra-precise scans and theranostics (a term that melds the words therapeutics and diagnostics). Together, they offer a one-two punch by integrating imaging and radiotracers that can identify the location and extent of diseased tissues and selectively destroy the abnormal cells while leaving surrounding healthy cells undamaged. In collaboration with GE HealthCare, St. Joseph’s is developing Canada’s first GE HealthCare Centre of Excellence in Molecular Imaging and Theranostics.

“By bridging the gap between research and clinical practice, we hope to ease the burden on patients and their families, offering more effective and compassionate care” 
-Ting-Yim Lee, PhD, Director of PET/CT Research at Lawson Research Institute.

“We are already seeing the impact of novel theranostics  for treatment of men with advanced prostate cancer,” says Bauman. “Promising new theranostic approaches are emerging for many cancers and this investment further positions London to be a leader in this area of research.”

In the initial phase of the studies, 100 patients will be recruited from St. Joseph’s Aging Brain and Memory Clinic at Parkwood Institute for the Alzheimer’s study; while 90 patients will be recruited from London Health Sciences Centre’s Verspeeten Family Cancer Centre for cancer studies. There are plans to recruit patients from the collaborating centres once results from the initial phase are confirmed.

“By bridging the gap between research and clinical practice, we hope to ease the burden on patients and their families, offering more effective and compassionate care,” says Lee. “We are deeply grateful for the opportunity to turn our research into real-world solutions that can make a meaningful impact.”

With dozens of 'firsts' in imaging research, “Lawson is a powerhouse of innovation,” adds Michael Kovacs, PhD, Program Lead, Lawson’s Imaging Research Program, and Lead, Cyclotron & PET Radiochemistry Facility. “We're excited to explore how this work could transform care."

Through donor support, endowed research chairs are exploring and answering some of the most profound and complex research questions of our time.

Among cherished family photos and special mementos in the office of Jeremy Burton, PhD, is a slightly faded photo of a young woman. Burton points out the framed photo as he enthusiastically talks about his work. It’s a young Miriam Burnett, after whom the Miriam Burnett Chair in Urological Sciences is named. It’s also the first endowed research chair position Burton held at St. Joseph’s Health Care London (St. Joseph’s).

As the research chair for seven years, Burton speaks fondly about the relationship he has with the Burnett family and the crucial role their support has played in advancing his research. 

“Thanks to their funding, we became one of the world leaders in urological microbiome research,” he says.

Endowed research chairs at St. Joseph’s receive consistent and sustainable funding so that research leaders and their teams can answer the most profound and complex health questions of our time.  

For decades, donors have been inspired by the clinical research taking place at St. Joseph’s and have heavily invested in endowed research chairs. Today, St. Joseph’s Health Care Foundation manages seven endowed chairs focused on several areas, including molecular imaging, fetal and newborn growth and diabetes. Working in partnership with Western University, and with donor support, the foundation recently established four new endowed chairs in mobility, medical biophysics, medical imaging and ophthalmology.

“Medical research in Canada is chronically underfunded, and there is almost no sustainable funding for hospital-based research positions,” says Michelle Campbell, President & CEO, St. Joseph’s Health Care Foundation. “Private philanthropy has filled that gap for years. When a donor gives to an endowed research chair, they are building capacity in the present day and creating future value and opportunity. An endowed gift has a multiplier effect.”

Burton, now the endowed Research Chair in Human Microbiome and Probiotics, has many reasons to be grateful for this support. Not only does the endowed fund pay for Burton’s research salary, it also partially supports the salaries of a lab manager and technical team – all vital for a sophisticated lab to be successful. 

The funding also provides the gift of time – a diminishing commodity for any busy research team. 

“Scientists need more time to think,” says Burton, a Lawson Research Institute (Lawson) scientist. “We are incrementally being stretched in multiple directions, and the funding gives us the time to do what we are meant to do – find answers to important clinical questions and find solutions to medical problems.” 

Distinguished Lawson scientist and university professor Cheryl Forchuk, PhD, wholeheartedly agrees. She recently completed her final term as The Beryl and Richard Ivey Research Chair in Aging, Mental Health, Rehabilitation & Recovery, another endowed position. As Chair, Forchuk provided scientific and administrative leadership to a large group of researchers based at St. Joseph’s Parkwood Institute focused on mental health, activity and mobility, and cognitive vitality and brain health.  
Many research leaders, she explains, can afford to spend only two days a week on their own research projects. Endowed chair positions change that. 

“Imagine travelling across the country to create a national study focused on homelessness, two days a week at a time,” she suggests candidly. “You couldn’t.” 

Forchuk is referring to her landmark project to better understand how many people in Canada are homeless and who they are. The goal was to develop more accurate sources of data and recommend appropriate support and services. Her work is already resulting in important changes.

Today, Forchuk is embarking on another cross-country research project to find solutions related to homelessness for Canadian veterans who are women. 

Like Forchuk, Burton’s Chair position requires him to provide operational and research leadership, including developing research networks and partnerships nationally and internationally to advance studies that will revolutionize care. 

“As the Chair, I think it is important that I have wide-ranging projects that benefit people in our own community and beyond,” says Burton, who is optimistic about the outcomes of several of his team’s studies. 

He recently partnered with London’s First Episode Mood and Anxiety Program to study the impact of fermented foods on the microbiome of young people taking medications for mental health conditions. 

One of the side effects of these medications is weight gain, which deters some patients from taking it. By providing patients with slow-release apple cider capsules, which have similar properties to fermented foods and positively affect the microbiome, they have seen an overall improvement in participants’ mental health and cholesterol after just a few months.

Reflecting on his team’s research achievements to date and the potential of what’s to come, Burton emphasizes how vital endowed chairs are to the sustainability of research and the hope to translate newly discovered knowledge into medical practice. 

“Research funding from other sources comes and goes,” he says, “but endowed chair positions that are focused on improving human health provide continuity, build research and create change benefiting all of us.”