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Dr. Thomas Gantert
- Therapeutic relationships
- Family caregivers
- Team functioning
- In-home care
Dr. Ting-Yim Lee awarded the Meritorious Service Cross by the Governor General of Canada
Congratulations to Dr. Ting-Yim Lee who was awarded the Meritorious Service Cross from the Governor General of Canada. He was recognized for his development of CT Perfusion to measure blood flow in the body which has transformed the way stroke is assessed and treated around the globe.
The Civil Division Cross recognizes a deed or an activity that has been performed in an outstandingly professional manner, or with uncommonly high standards; the activity is often innovative, sets an example for others to follow, improves the quality of life of a community and brings considerable benefit or honour to Canada.
Dr. Lee, a scientist at Lawson Health Research Institute and Medical Physicist at St. Joseph’s Health Care London, as well as professor at Western University’s Schulich School of Medicine & Dentistry and scientist at Robarts Research Institute, fits the bill perfectly. Through his research program, Dr. Lee pioneered the development of CT Perfusion technology which is compatible with existing CT scanners and uses X-ray dye to assist doctors in assessing blood flow in the event of stroke.
The technology is now in use in more than 8,000 hospital imaging departments worldwide and has drastically improved patient care.
“I am humbled by this award. The work I’ve accomplished would not have been possible without the support of the institutions and collaboration of colleagues too many to name and the tireless effort of all members of my lab: graduate students, fellows, technicians and assistants,” said Dr. Lee. “I am really happy that this work has been found to help patient care. It gives me impetus to continue to search for new innovations that would benefit patients.”
The Meritorious Service Decorations recognize Canadians for exceptional deeds that bring honour to the country. The cross was originally created in 1984 by Her Majesty Queen Elizabeth II, for members of the military. In 1991, both the cross and medal were introduced for civilians to recognize remarkable contributions in many different fields including advocacy initiatives and health care services, to research and humanitarian efforts.
The recipients of the awards were announced by Governor General of Canada, David Johnston, and will be presented at an official ceremony later this year.
Dr. Ting-Yim Lee recognized by WORLDiscoveries for medical imaging innovation
An exceptional career of innovation prowess, influence and leadership has won Dr. Ting-Yim Lee the inaugural Career Achievement Award presented by WorldDiscoveries.
Dr. Lee, Director of PET/CT Research at Lawson Health Research Institute and Medical Physicist at St. Joseph’s Health Care London, is being recognized for the significance of his work in the field of medical imaging and outstanding success in turning innovative ideas into tangible products and services.
Each year, WORLDiscoveries, the technology transfer and business development office for Western University, Lawson, and Robarts Research Institute, hosts the Vanguard Awards. These prestigious awards honour the community’s brightest minds, visionary entrepreneurs, and the exceptional achievements they have made in technology and research. By partnering with WORLDiscoveries, recipients of the Vanguard Awards have reached significant market-readiness milestones, propelling their ideas toward real-world impact. All recipients have made remarkable strides in their respective fields, shaping the future of innovation.
Dr. Lee pioneered use of advanced methods to analyze medical images from machines like CT, MRI and PET to gather important information about diseases. Over the years, he has published 290 research papers, which have been cited nearly 19,000 times – an indication of their impact in the medical community.
His work initially focused on using dynamic CT scans to study blood flow in stroke and cancer patients and to address challenges related to imaging the heart. With dynamic CT scans, images are taken continuously as change in vessels, organs and other structures is happening. The effect is similar to a real-time video. Dr. Lee also played a role in developing guidelines for using these scans to study the growth of new blood vessels that nourish the proliferation of cancer cells.
More recently, he shifted his focus to PET scans to examine biological processes in the body, demonstrating their effectiveness in detecting prostate cancer in a short, 22-minute scan. One of his notable contributions was the development of CT Perfusion software, which played a crucial role in a U.S. nation-wide ovarian cancer trial involving more than 20 medical centres. This software proved valuable as an early biomarker for assessing treatment response.
In addition to research, this world-renowned researcher has obtained eight patents and has licensed five enhanced versions of the CT Perfusion software to GE HealthCare, making it easier for clinicians to apply his techniques in real-world hospital settings.
Dedicated to creating the next generation of scientists, Dr. Lee has mentored and trained 70 graduate students, post-doctoral fellows, clinicians and research associates, many of them going on to earn prestigious research awards themselves.
“I am grateful for the support received over the decades from colleagues and trainees,” says Dr. Lee. “Without them, the work cannot be done. This award is not just for myself but for all collaborators and contributors on this journey.”
In presenting the award, WORLDiscoveries says Dr. Lee’s work has transformed industries, inspired countless individuals within the field to pursue innovation and entrepreneurship, and has left a lasting impact on society at large.
St. Joseph’s congratulates this remarkable and dedicated scientist on this prestigious and well-deserved award.
More on the Vanguard Awards and the 2023 recipients are available on the WORLDiscoveries website.
Dr. Tisha Joy
- Adipose distribution
- Insulin resistance
- Dyslipidemia
- Obesity
Dr. Tom Sheidow
- Age related mascular degeneration
- Macular holes
- Retinal detachment
- Diabetic retinopathy
- Retinal vascular disease
Dr. Jeremy Burton
BSc, MSc, PhD, dBA
Contact Information
We conduct research on the role of microbes in various human conditions. Our primary focus is the microbiome which influences urological conditions. The microbiome at distal sites is now the most intriguing, as it is thought to have an influence on systemic health well beyond the primary mucosal sites they occupy.
Dr. Burton's appreciation of the microbial ecology of humans as a student was sparked by Professors Gerald Tannock and John Tagg at University of Otago in New Zealand.
In the early 2000s, he was fortunate enough to study the vaginal microbiota with then-emerging non-culture-based techniques. These showed that difficult-to-culture organisms, such as Lactobacillus iners, were frequent inhabitants of woman, but were not often detected by bacteriological culture-based methods.
After spending time in Industry he returned to the Lawson Health Research Institute and the Canadian Centre for Human Microbiome and Probiotics to continue working on the exciting area of translating microbial ecological research into real-world applications.
Our primary collaborators are with clinicians within the Division of Urology and Scientists within the Department of Microbiology and Immunology and wider Western University.
We also have collaborations with the J. Craig Venter Institute (US), University of Otago (NZ), University of British Columbia and Sichuan University (China).
Dr. Vladimir Hachinski receives Canadian Medical Association’s highest honour
World-renowned brain researcher, Dr. Vladimir Hachinski, is named as this year’s recipient of the Canadian Medical Association’s (CMA) F.N.G. Starr Award for his contributions in stroke research and patient care. This prestigious award is the highest available to CMA members and is intended to recognize outstanding and inspiring lifetime achievement.
Dr. Hachinski, Lawson Scientist and Neurologist at London Health Sciences Centre is the co-founder of the world’s first successful stroke unit. Two earlier centres in the United States were deemed unsuccessful and eventually closed. Dr. Hachinski and his colleague, Dr. John W. Norris, applied their knowledge and fresh perspectives, and opened a stroke centre at Sunnybrook Hospital, Toronto, in 1975.
“We had a tremendous team of volunteer nurses, physiotherapists and other professionals who were very keen to have an impact,” explains Dr. Hachinski. “We implemented the A, B, C, protocol which focused on Accurate diagnosis, Balance and homeostasis in the patient’s physiology, and avoiding Complication. Dr. Josephine Somerville pioneered early rehabilitation in the stroke unit.”
At the time, stroke was still commonly misunderstood in medicine, until Dr. Hachinski coined the term “brain attack” in 1993, describing the similarities in urgency of strokes and heart attacks.
Realizing the success of their protocols on stroke patients, Dr. Hachinski and his colleagues also noticed improved outcomes for dementia rates in the stroke patients they saw. There is still no treatment for dementia, however they were confident they could delay onset through similar stroke prevention and treatment protocols.
After several studies on both animal models and humans, Dr. David Cechetto from Western University and Dr. Hachinski discovered that the region of the brain, known as the insula, is involved in regulating the parasympathetic and sympathetic nervous systems - evidence that there is an important connection in how the brain impacts the heart.
Today there are several stroke centres operating in Ontario. “We were able to prove that our model was successful at improving the lives of stroke patients, so the government facilitated the opening of these centres across the province. We can now say that we have improved outcomes not just for individuals, but at a population level, where public health policy has its true impact,” says Dr. Hachinski.
Currently Dr. Hachinski and his team are seeking funding for a nation-wide study to examine stroke and dementia outcomes across the country, including how several environmental factors play a role in the development of stroke and dementia with the aim of preventing both. “Since this research is multi-disciplinary, it is challenging to find a funding agency as most of them tend to invest in very specific fields of research,” he explains. “We are hopeful that someone will recognize the importance of this research, and we will be able to move forward with our study.”
“I am extremely appreciative and proud to be recognized with the F.N.G. Starr Award, however I am just the face of this honour. Behind me stands an amazing team. I feel that my greatest strength is to recognize and work with talent.”
Dr. Warren Nielson
- Pain
- Health psychology
- Rheumatic diseases (e.g., Arthritis, Fibromyalgia, Lupus, Scleroderma)
Dr. William Pavlosky
M.D.
Dr. Laura Graham
PT
Mobility and Activity
As a physiotherapist, Laura has primarily worked in adult brain injury since 2011. Her teaching focus is physiotherapy foundational clinical skills and applied neurological injury/illness rehabilitation; and her research focus is interventions for adults with persistent symptoms post concussion/mild traumatic brain injury. She has consulted with WSIB Ontario on mTBI Program of Care revision, presented at See The Line concussion symposium, and taught physiotherapist instructors across Canada about concussion/mTBI rehabilitation for the National Orthopaedic Division of the Canadian Physiotherapy Association.
Dr. Dalton Wolfe (Lawson); Dr. Jim Dickey (Western)
Drug combats underlying causes of Alzheimer-related dementia
A “game-changing” new drug offers both hope and time to some people diagnosed with Alzheimer’s disease, says the head of a St. Joseph’s program that played a key role in the medication’s clinical trials. Health Canada has newly approved lecanemab (brand name Leqembi, developed by Eisai Co. and Biogen), which has been shown to slow progression of Alzheimer’s disease in people with mild symptoms.
St. Joseph’s Health Care London, and its innovation arm at Lawson Research Institute, has played a key role as one of multiple sites that have trialed the drug.
“This is game-changing,” says Dr. Michael Borrie, medical director of the Aging Brain and Memory Clinic at St. Joseph’s, whose work in dementia research and clinical practice spans more than three decades.
“We’ve been working for over 20 years to find a compound that is disease-modifying. This is the first approved drug in Canada that addresses the underlying pathology of Alzheimer’s, not just the symptoms.”
Lecanemab works by removing amyloid proteins that accumulate as sticky clumps in the brain and are associated with cognitive decline in people with Alzheimer’s. “It reverses one aspect of the disease by removing the plaque from the brain ,” Borrie explains.
“You can characterize its benefit in terms of time saved. If you were to have this medication for four years, you can ‘save’ one year of cognitive decline. It totally changes the course of their neurodegeneration in a way we haven’t seen before.”
Lecanemab was one of many clinical drug trials assigned to research coordinator Kayla Vander Ploeg when she arrived to work at St. Joseph’s more than a decade ago. “For so long, we had hope that one of these medications would benefit patients long-term. Now we have more than hope. We have results,” Vander Ploeg says.
“Today I’m seeing people who say, ‘my dad or my mom was in this study, and now there’s hope for me.’ ”
There are specific eligibility criteria, including confirmed diagnosis – through cognitive testing and through advanced brain imaging and biomarker tests – plus screening to rule out two gene variations that couldresult in more side effects.
Canada is now one of 51 countries to have approved lecanemab.
Borrie cautioned that Health Canada approval doesn’t necessarily translate to funding coverage. It’s not yet determined who will pay for the medication, or how: when lecanemab was approved in the United States in 2023, the annual cost per patient was more than $26,000.
The length of time from drug development to trials to approval illustrates how painstaking pharmaceutical research can be. But it also highlights how integrating health research into hospital settings can translate more quickly into improved patient care.
Easing the pressure for patients with chronic wounds
Chronic wounds represent a significant burden in Canada. Between four and 30 per cent of patients develop a chronic wound, depending on the health care setting. Over 85 per cent of all Spinal Cord Injury (SCI) survivors will experience health complications related to pressure ulcers, injuries to the skin and underlying tissue resulting from prolonged pressure. These types of wounds can significantly reduce participation in meaningful activities and overall quality of life.
Research from around the world shows that electrical stimulation can help speed the healing of pressure ulcers. This therapy is currently done by a trained health care provider and is not readily available for people across Canada.Electrical stimulation therapy (E-Stim) is a wound treatment that involves applying low levels of electrical current to the wound bed and surrounding tissues. It stimulates several healing processes, promotes local circulation and prevents infections.
The E-Stim Collaboration: A Best Practice Implementation Project for Better Pressure Ulcer Care aims to improve the coordination of pressure ulcer care and promote the use of evidence-informed wound treatments for people living with SCI. In particular, the research project is studying how to best provide E-Stim to people with pressure ulcers, in their own communities.
“Over the years I’ve seen the serious impact pressure ulcers have on the lives of people with spinal cord injury and other health challenges. This is what drives my commitment to not only develop best practice guidelines, but also to ensure they are put into action,” says Dr. Pamela Houghton, Associate Scientist, Lawson and Professor, School of Physical Therapy at Western University. “Advances in technology make it possible for more people with care needs to live at home.”
The pilot project in the South West LHIN has a unique model that builds capacity in the community and taps into the lived experience of people with pressure ulcers and SCI. It brings together the expertise of researchers, clinicians and managers from academia, hospital centres and community care.
Partners include the Parkwood Institute Research program at Lawson Health Research Institute, Western University, Saint Elizabeth’s Health Care Research Centre, Sunnybrook Health Sciences Centre and the South West Community Care Access Centre. An interdisciplinary specialized team, called SCIPUT, has been established within the Spinal Cord Injury Rehabilitation program provided at Parkwood Institute, St. Joseph’s Health Care London.
“Our collaborative team is using the PLAN-DO-STUDY-ACT quality improvement model. This allows us to learn from each cycle and make adjustments as we go,” says Dr. Houghton. “We have just completed the first cycle and are reporting on lessons learned.” Funded by the Rick Hansen Foundation, the team hopes this will set the stage for a larger cross-country initiative.
Those interested in participating can contact phoughto@uwo.ca. The study is open to:
- Individuals with an open pressure ulcer and with a condition that causes limited mobility and/or requires a wheelchair;
- Those who are able and willing to participate in treatment plan, and communicate feedback; and,
- People who are eligible to receive services from South West CCAC.
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Electrical stimulation (E-Stim) directly stimulates several wound healing processes, promotes local circulation and prevents wound infections. It produces faster healing and wound closure. A trained health care provider applies low levels of electrical current to the pressure ulcer using specialized equipment. |
Eldon Loh
Eldon Loh , MD
Associate Professor, Schulich School of Medicine and Dentistry
Chronic Pain
Dr. Eldon Loh is a Physiatrist at Parkwood Institute and an Associate Professor in the Department of Physical Medicine and Rehabilitation at the Schulich School of Medicine and Dentistry at Western University. He completed residency training in Physical Medicine and Rehabilitation at the University of Alberta in 2010 and a clinical fellowship in interventional pain management in 2011. His research interests include improving the management of chronic neuropathic pain after spinal cord injury, and the development of novel and improved techniques for interventional pain management of axial spine pain.
He is Chair of the panel that developed and updates the Canadian Best Practice Guidelines for Neuropathic Pain after spinal cord injury and works with international partners to improve point-of-care tools for implementing the guidelines. His interventional pain research focuses heavily on a bench to bedside approach, utilizing anatomical findings to inform clinical practice. He has also examined the impact of Ontario’s healthcare utilization of different interventional procedures such as radiofrequency ablation and paravertebral nerve blocks.
Embracing health research this holiday season
Community members, patients and families, and those working in the health field attended a special open house on November 28 by research groups at Lawson Health Research Institute. Together, they celebrated the holiday spirit and the gift of hope that is made possible through hospital-based research.
A part of St. Joseph’s Health Care London, Parkwood Institute represents the next era in care, recovery and rehabilitation. Across the site, clinical and research teams in different disciplines and specialties collaborate not only with each other but also with patients and families.
“Many people in the community know the high-quality and compassionate care that is supported by the various clinical teams at Parkwood Institute, but aren’t aware of the research happening at this site,” says Dr. Cheryl Forchuk, Beryl and Richard Ivey Research Chair in Aging, Mental Health, Rehabilitation and Recovery, and Assistant Scientific Director at Lawson.
“Lawson researchers at Parkwood are tackling important challenges with highly innovative and meaningful solutions that help improve care and quality of life.”
For the past three years, the open house gives guests a more in-depth understanding of hospital-based research and its impact. Dr. Forchuk notes that it is a great chance to talk to the researchers and their teams, and to learn about research in a really fun and interactive way. Guests may also learn about opportunities to participate in studies, as the research teams rely on people in the community getting involved.
There were 12 interactive program displays from Parkwood Institute Research, a Lawson program, in the areas of cognitive vitality and brain health, mobility and activity and mental health:
- Cognitive Clinical Trials Group (CCTG)
- Collaboration of Rehabilitation Research Evidence (CORRE)
- Gait and Brain Lab
- Geriatric Mood Disorders Lab
- MacDonald Franklin OSI Research Centre (Occupational Stress Injury)
- Mental Health Nursing Research Alliance (MHNRA)
- Mental Health INcubator for Disruptive Solutions (MINDS) of London
- Neuropsychiatry and Therapeutic Brain Stimulation Research Group
- Occupational Therapy and Spiritual Care Research Lab
- R2P (Research to Practice)
- Rehabilitation Mental Health
- Wound Care
The open house had a festive theme and many of the exhibits involved a problem solving or interactive elements to encourage learning and foster teamwork.
Karen Vecchio, federal Member of Parliament for Elgin-Middlesex-London, was among the over 200 people in attendance.
At the open house, from left: Dr. Cheryl Forchuk, MP Karen Vecchio and Roy Butler, St. Joseph's Vice President.
“London is a great community to conduct research,” explains Dr. Forchuk. “We are a mid-size city surrounded by rural areas, in many ways reflecting Canada as a whole. A lot of our projects cover the country with multiple sites and results found here by our leading experts are being implemented in health centres and national strategies in this country and around the world.”