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Dr. Ting-Yim Lee recognized by WORLDiscoveries for medical imaging innovation
An exceptional career of innovation prowess, influence and leadership has won Dr. Ting-Yim Lee the inaugural Career Achievement Award presented by WorldDiscoveries.
Dr. Lee, Director of PET/CT Research at Lawson Health Research Institute and Medical Physicist at St. Joseph’s Health Care London, is being recognized for the significance of his work in the field of medical imaging and outstanding success in turning innovative ideas into tangible products and services.
Each year, WORLDiscoveries, the technology transfer and business development office for Western University, Lawson, and Robarts Research Institute, hosts the Vanguard Awards. These prestigious awards honour the community’s brightest minds, visionary entrepreneurs, and the exceptional achievements they have made in technology and research. By partnering with WORLDiscoveries, recipients of the Vanguard Awards have reached significant market-readiness milestones, propelling their ideas toward real-world impact. All recipients have made remarkable strides in their respective fields, shaping the future of innovation.
Dr. Lee pioneered use of advanced methods to analyze medical images from machines like CT, MRI and PET to gather important information about diseases. Over the years, he has published 290 research papers, which have been cited nearly 19,000 times – an indication of their impact in the medical community.
His work initially focused on using dynamic CT scans to study blood flow in stroke and cancer patients and to address challenges related to imaging the heart. With dynamic CT scans, images are taken continuously as change in vessels, organs and other structures is happening. The effect is similar to a real-time video. Dr. Lee also played a role in developing guidelines for using these scans to study the growth of new blood vessels that nourish the proliferation of cancer cells.
More recently, he shifted his focus to PET scans to examine biological processes in the body, demonstrating their effectiveness in detecting prostate cancer in a short, 22-minute scan. One of his notable contributions was the development of CT Perfusion software, which played a crucial role in a U.S. nation-wide ovarian cancer trial involving more than 20 medical centres. This software proved valuable as an early biomarker for assessing treatment response.
In addition to research, this world-renowned researcher has obtained eight patents and has licensed five enhanced versions of the CT Perfusion software to GE HealthCare, making it easier for clinicians to apply his techniques in real-world hospital settings.
Dedicated to creating the next generation of scientists, Dr. Lee has mentored and trained 70 graduate students, post-doctoral fellows, clinicians and research associates, many of them going on to earn prestigious research awards themselves.
“I am grateful for the support received over the decades from colleagues and trainees,” says Dr. Lee. “Without them, the work cannot be done. This award is not just for myself but for all collaborators and contributors on this journey.”
In presenting the award, WORLDiscoveries says Dr. Lee’s work has transformed industries, inspired countless individuals within the field to pursue innovation and entrepreneurship, and has left a lasting impact on society at large.
St. Joseph’s congratulates this remarkable and dedicated scientist on this prestigious and well-deserved award.
More on the Vanguard Awards and the 2023 recipients are available on the WORLDiscoveries website.
Drug combats underlying causes of Alzheimer-related dementia
A “game-changing” new drug offers both hope and time to some people diagnosed with Alzheimer’s disease, says the head of a St. Joseph’s program that played a key role in the medication’s clinical trials. Health Canada has newly approved lecanemab (brand name Leqembi, developed by Eisai Co. and Biogen), which has been shown to slow progression of Alzheimer’s disease in people with mild symptoms.
St. Joseph’s Health Care London, and its innovation arm at Lawson Research Institute, has played a key role as one of multiple sites that have trialed the drug.
“This is game-changing,” says Dr. Michael Borrie, medical director of the Aging Brain and Memory Clinic at St. Joseph’s, whose work in dementia research and clinical practice spans more than three decades.
“We’ve been working for over 20 years to find a compound that is disease-modifying. This is the first approved drug in Canada that addresses the underlying pathology of Alzheimer’s, not just the symptoms.”
Lecanemab works by removing amyloid proteins that accumulate as sticky clumps in the brain and are associated with cognitive decline in people with Alzheimer’s. “It reverses one aspect of the disease by removing the plaque from the brain ,” Borrie explains.
“You can characterize its benefit in terms of time saved. If you were to have this medication for four years, you can ‘save’ one year of cognitive decline. It totally changes the course of their neurodegeneration in a way we haven’t seen before.”
Lecanemab was one of many clinical drug trials assigned to research coordinator Kayla Vander Ploeg when she arrived to work at St. Joseph’s more than a decade ago. “For so long, we had hope that one of these medications would benefit patients long-term. Now we have more than hope. We have results,” Vander Ploeg says.
“Today I’m seeing people who say, ‘my dad or my mom was in this study, and now there’s hope for me.’ ”
There are specific eligibility criteria, including confirmed diagnosis – through cognitive testing and through advanced brain imaging and biomarker tests – plus screening to rule out two gene variations that couldresult in more side effects.
Canada is now one of 51 countries to have approved lecanemab.
Borrie cautioned that Health Canada approval doesn’t necessarily translate to funding coverage. It’s not yet determined who will pay for the medication, or how: when lecanemab was approved in the United States in 2023, the annual cost per patient was more than $26,000.
The length of time from drug development to trials to approval illustrates how painstaking pharmaceutical research can be. But it also highlights how integrating health research into hospital settings can translate more quickly into improved patient care.
Easing the pressure for patients with chronic wounds
Chronic wounds represent a significant burden in Canada. Between four and 30 per cent of patients develop a chronic wound, depending on the health care setting. Over 85 per cent of all Spinal Cord Injury (SCI) survivors will experience health complications related to pressure ulcers, injuries to the skin and underlying tissue resulting from prolonged pressure. These types of wounds can significantly reduce participation in meaningful activities and overall quality of life.
Research from around the world shows that electrical stimulation can help speed the healing of pressure ulcers. This therapy is currently done by a trained health care provider and is not readily available for people across Canada.Electrical stimulation therapy (E-Stim) is a wound treatment that involves applying low levels of electrical current to the wound bed and surrounding tissues. It stimulates several healing processes, promotes local circulation and prevents infections.
The E-Stim Collaboration: A Best Practice Implementation Project for Better Pressure Ulcer Care aims to improve the coordination of pressure ulcer care and promote the use of evidence-informed wound treatments for people living with SCI. In particular, the research project is studying how to best provide E-Stim to people with pressure ulcers, in their own communities.
“Over the years I’ve seen the serious impact pressure ulcers have on the lives of people with spinal cord injury and other health challenges. This is what drives my commitment to not only develop best practice guidelines, but also to ensure they are put into action,” says Dr. Pamela Houghton, Associate Scientist, Lawson and Professor, School of Physical Therapy at Western University. “Advances in technology make it possible for more people with care needs to live at home.”
The pilot project in the South West LHIN has a unique model that builds capacity in the community and taps into the lived experience of people with pressure ulcers and SCI. It brings together the expertise of researchers, clinicians and managers from academia, hospital centres and community care.
Partners include the Parkwood Institute Research program at Lawson Health Research Institute, Western University, Saint Elizabeth’s Health Care Research Centre, Sunnybrook Health Sciences Centre and the South West Community Care Access Centre. An interdisciplinary specialized team, called SCIPUT, has been established within the Spinal Cord Injury Rehabilitation program provided at Parkwood Institute, St. Joseph’s Health Care London.
“Our collaborative team is using the PLAN-DO-STUDY-ACT quality improvement model. This allows us to learn from each cycle and make adjustments as we go,” says Dr. Houghton. “We have just completed the first cycle and are reporting on lessons learned.” Funded by the Rick Hansen Foundation, the team hopes this will set the stage for a larger cross-country initiative.
Those interested in participating can contact phoughto@uwo.ca. The study is open to:
- Individuals with an open pressure ulcer and with a condition that causes limited mobility and/or requires a wheelchair;
- Those who are able and willing to participate in treatment plan, and communicate feedback; and,
- People who are eligible to receive services from South West CCAC.
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Electrical stimulation (E-Stim) directly stimulates several wound healing processes, promotes local circulation and prevents wound infections. It produces faster healing and wound closure. A trained health care provider applies low levels of electrical current to the pressure ulcer using specialized equipment. |
Embracing health research this holiday season
Community members, patients and families, and those working in the health field attended a special open house on November 28 by research groups at Lawson Health Research Institute. Together, they celebrated the holiday spirit and the gift of hope that is made possible through hospital-based research.
A part of St. Joseph’s Health Care London, Parkwood Institute represents the next era in care, recovery and rehabilitation. Across the site, clinical and research teams in different disciplines and specialties collaborate not only with each other but also with patients and families.
“Many people in the community know the high-quality and compassionate care that is supported by the various clinical teams at Parkwood Institute, but aren’t aware of the research happening at this site,” says Dr. Cheryl Forchuk, Beryl and Richard Ivey Research Chair in Aging, Mental Health, Rehabilitation and Recovery, and Assistant Scientific Director at Lawson.
“Lawson researchers at Parkwood are tackling important challenges with highly innovative and meaningful solutions that help improve care and quality of life.”
For the past three years, the open house gives guests a more in-depth understanding of hospital-based research and its impact. Dr. Forchuk notes that it is a great chance to talk to the researchers and their teams, and to learn about research in a really fun and interactive way. Guests may also learn about opportunities to participate in studies, as the research teams rely on people in the community getting involved.
There were 12 interactive program displays from Parkwood Institute Research, a Lawson program, in the areas of cognitive vitality and brain health, mobility and activity and mental health:
- Cognitive Clinical Trials Group (CCTG)
- Collaboration of Rehabilitation Research Evidence (CORRE)
- Gait and Brain Lab
- Geriatric Mood Disorders Lab
- MacDonald Franklin OSI Research Centre (Occupational Stress Injury)
- Mental Health Nursing Research Alliance (MHNRA)
- Mental Health INcubator for Disruptive Solutions (MINDS) of London
- Neuropsychiatry and Therapeutic Brain Stimulation Research Group
- Occupational Therapy and Spiritual Care Research Lab
- R2P (Research to Practice)
- Rehabilitation Mental Health
- Wound Care
The open house had a festive theme and many of the exhibits involved a problem solving or interactive elements to encourage learning and foster teamwork.
Karen Vecchio, federal Member of Parliament for Elgin-Middlesex-London, was among the over 200 people in attendance.
At the open house, from left: Dr. Cheryl Forchuk, MP Karen Vecchio and Roy Butler, St. Joseph's Vice President.
“London is a great community to conduct research,” explains Dr. Forchuk. “We are a mid-size city surrounded by rural areas, in many ways reflecting Canada as a whole. A lot of our projects cover the country with multiple sites and results found here by our leading experts are being implemented in health centres and national strategies in this country and around the world.”