Search
Search
Locally developed test found to increase diagnosis of rare hereditary disorders
LONDON, ON – A clinical trial named “EpiSign-CAN,” led by researchers at Lawson Health Research Institute (Lawson) has been awarded $4.8 million to measure the clinical impact of a new molecular genomics test for diagnosing genetic neurodevelopmental conditions.
Developed at Lawson, the diagnostic test, called EpiSign, uses machine learning to analyze the EpiSign Knowledge Database. This database compiles information on rare genetic diseases using laboratory analyses of the entire genome, referred to as the epigenome, from patients with suspected genetic abnormalities.
A recent paper describes the newly discovered biomarkers for over 50 neurodevelopmental conditions. Dr. Bekim Sadikovic, Lawson Scientist and Head of the Molecular Diagnostics Division at London Health Sciences Centre (LHSC) explains, “before this study, many such conditions required targeted, and often labour intensive and costly assays for a diagnosis, which in many cases provided no conclusive answers. Now, using our EpiSign Knowledge Database which includes the epigenomic information of thousands of patients and controls, we are able to diagnose over 50 conditions with a single test, including in patients where targeted genetic testing was inconclusive.”
The upcoming clinical trial hopes to validate the use of this test in the first-line of diagnosing rare genetic disorders across Canada. “Patients and families typically wait years, and undergo multiple exams and lab tests in search of a definitive diagnosis. With EpiSign, we estimate that we will be able to increase the number of people who receive a diagnoses by five per cent, or more in the future as the database develops” explains Dr. Sadikovic. “Though individual genetic conditions are rare, there are over 4,000 recognized genetic disorders which affect thousands of patients in Canada.”
EpiSign-CAN will study 4,000 patients, who will either receive EpiSign testing as part of the initial diagnostic workup or after classical genetic testing approaches have been exhausted. The goal is to assess the impact of using EpiSign in the first stage of diagnosis vs. after other tests have failed to provide answers in this patient population.
Timely diagnosis will prevent the so called “diagnostic odyssey,” and by doing so has the potential to improve healthcare outcomes for these patients and decrease cost to the health system.
As the EpiSign Knowledge Database continues to grow, researchers are finding correlations between specific episignatures, or molecular DNA markers, and related physiological features across a syndrome.
This research is co-funded through the collaboration of three partners; LHSC, Illumina, and Genome Canada. This is the first time researchers at Lawson have been awarded a Genome Canada Genomic Applications Partnership Program (GAPP) grant. “Genome Canada focuses its resources on new innovation that has a strong likelihood of translating directly to patient care. Their support of our work is extremely meaningful,” says Dr. Sadikovic.
The study describing the most recent advancements in EpiSign technology, “Evaluation of DNA methylation episignatures for diagnosis and phenotype correlations in 42 Mendelian neurodevelopmental disorders,” is published in The American Journal of Human Genetics.
-30-
Lawson Health Research Institute is one of Canada’s top hospital-based research institutes, tackling the most pressing challenges in health care. As the research institute of London Health Sciences Centre and St. Joseph’s Health Care London, our innovation happens where care is delivered. Lawson research teams are at the leading-edge of science with the goal of improving health and the delivery of care for patients. Working in partnership with Western University, our researchers are encouraged to pursue their curiosity, collaborate often and share their discoveries widely. Research conducted through Lawson makes a difference in the lives of patients, families and communities around the world. To learn more, visit www.lawsonresearch.ca.
Senior Media Relations Consultant
Communications & Public Engagement
T: 519-685-8500 ext. 73502
Celine.zadorsky@lhsc.on.ca
London comes in eighth place in Canada’s Top 40 for hospital-based research
Lawson Health Research Institute has ranked eighth in the country for the 2021 edition of Canada’s Top 40 Research Hospitals List by Re$earch Infosource. This is the eighth consecutive year that Lawson has maintained this strong national position, which puts the institute within the top five in Ontario.
Lawson, the research institute of London Health Sciences Centre (LHSC) and St. Joseph’s Health Care London, has also maintained the top ranking for research intensity among the large tier institutions with a little more than $600,000 of research spending per researcher.
“This is a validation of the extensive support from LHSC and St. Joseph’s, our hospital foundations, Western University and our staff and physicians,” says Lawson’s Scientific Director Dr. David Hill. “These strong partnerships make the hospital environment in London a nationally recognized centre of discovery and knowledge translation.”
Hospital-based researchers belong to a health system at the forefront of the ongoing COVID-19 pandemic. With close proximity to patients and access to samples, they have mobilized to address COVID-19 in many different ways, and are making a difference around the world when it comes to advances and discoveries.
“The Province of Ontario designated health research as an essential service early in the pandemic,” explains Dr. Hill. “They understood that only science can get us through this, be it through vaccine development, surveillance and testing, evaluating new drugs to help patients in ICU survive, or studying the long-term health impacts. We have made substantial contributions of new knowledge through Lawson.”
The top 40 list analyzes hospital-based research institutes from across the country on several metrics, including total research income from the previous fiscal year. According to the report, Lawson received $121,888 million in research income in 2021.The ranking looks at funds received from all sources, including both internal and external, to support research at LHSC and St. Joseph’s.
Quick summary of Lawson’s ranking
- Rank in Top 40 Research Hospitals 2021: 8 (same as 2020)
- FY2020 research spending: $121.888 million
- Percentage change 2019-2020: 2.6%
- Research intensity: $618,700 per researcher
- Research intensity - percentage of total hospital spending: 7.0%
London expands approach to prevent discharge from hospital to homelessness
LONDON, ON - During a virtual event for Londoners hosted by Lawson Health Research Institute and the City of London, a multi-sectoral research team announced two projects representing a collaborative approach to preventing homelessness from within hospital walls.
Built on the unique and successful No Fixed Address (NFA) strategy, these projects are being tested as a potential best practice for preventing hospital discharge to homelessness. NFA seeks to stop the cycle between hospital admissions and homelessness by providing timely and accessible supports to patients who would otherwise be discharged into homelessness. It brings housing and financial supports into the health-care system, starting as soon as upon admission, to assist in finding appropriate housing and supports or avoiding a potential eviction.
“Canada lacks a validated and coordinated service model to address the issue of hospital stay to no fixed address, which can often be the beginning of an individual’s experience with homelessness,” explains Dr. Cheryl Forchuk, Beryl and Richard Ivey Research Chair in Aging, Mental Health, Rehabilitation and Recovery, and Assistant Scientific Director at Lawson. “There are multiple factors that cause people to be discharged into homelessness - systemic, organizational and personal. We need a collaborative and coordinated approach that honours housing as a basic human right.”
Several departments at London Health Sciences Centre (LHSC) and St. Joseph’s Health Care London collaborate with staff from the City of London, Canadian Mental Health Association (CMHA) Elgin-Middlesex, Youth Opportunities Unlimited (YOU), Salvation Army’s Housing Stability Bank and Ontario Works in the City of London to provide direct, on-site (or virtual) support for patients at risk of homelessness.
“Implementing a coordinated approach to addressing homelessness allows our staff to actively work alongside our partners in health care to prevent and divert individuals and families from an experience of homelessness by assessing their needs and connecting them to the housing supports.,” says John D’Oria, Coordinated Access Manager, City of London. “Whether it’s financial, social service or mental health support, this partnership and approach allows for a holistic approach to client care at the right time.”
Patients discharged from hospital to homelessness in Canada face many challenges that make recovery more difficult. They often experience higher readmission rates and emergency department visits. This is particularly concerning for youth, who have been found to be the fastest growing segment of the homeless population.
NFA was initially tested with strong success for mental health patients across the city and the second version of the project was extended to medical units at LHSC’s University and Victoria Hospitals.
PROJECT 1: Collaboration to Address Homelessness - Health, Housing and Income (H2I)
This research study will evaluate the City of London’s Coordinated Access Outreach program at hospital sites. A Coordinated Access Outreach worker will support individuals at risk of homelessness to maintain or obtain housing. Ontario Works will assist with the provision of income and employment supports and the Salvation Army Housing Stability Bank may be accessed for needed financial resources to secure or maintain housing.
Over two years, 106 participants will be interviewed in hospital and again six months post-discharge. Focus groups with participants, health care providers and community partners will provide further insight into the effectiveness of NFA. This project is funded by the Canada Mortgage and Housing Corporation (CMHC)’s National Housing Strategy.
PROJECT 2: Preventing discharge to No Fixed Address – Youth (NFA-Y)
This research study will customize, implement and evaluate the NFA strategy for vulnerable youth ages 16-24. The unique health and housing needs of youth at-risk will be explored by streamlining housing and financial support into a coordinated system of care, with additional support provided by Youth Opportunities Unlimited and Children’s Aid Society London and Middlesex.
Over 3-4 years, data to be collected from 93 youth at three time points. Focus groups with youth participants, health care providers, and community agency partners will help enhance the NFA strategy to meet the unique needs of youth. This project is funded by the National Centres of Excellence (NCE) Making the Shift (MtS) Youth Social Innovation Lab.
-30-
Lawson Health Research Institute is one of Canada’s top hospital-based research institutes, tackling the most pressing challenges in health care. As the research institute of London Health Sciences Centre and St. Joseph’s Health Care London, our innovation happens where care is delivered. Lawson research teams are at the leading-edge of science with the goal of improving health and the delivery of care for patients. Working in partnership with Western University, our researchers are encouraged to pursue their curiosity, collaborate often and share their discoveries widely. Research conducted through Lawson makes a difference in the lives of patients, families and communities around the world. To learn more, visit www.lawsonresearch.ca.
Senior Media Relations Consultant
Communications & Public Engagement
T: 519-685-8500 ext. 73502
Celine.zadorsky@lhsc.on.ca
London expands approach to prevent discharge from hospital to homelessness
During a virtual event for Londoners hosted by Lawson Health Research Institute and the City of London, a multi-sectoral research team announced two projects representing a collaborative approach to preventing homelessness from within hospital walls.
Built on the unique and successful No Fixed Address (NFA) strategy, these projects are being tested as a potential best practice for preventing hospital discharge to homelessness.
Led by Dr. Cheryl Forchuk, Beryl and Richard Ivey Research Chair in Aging, Mental Health, Rehabilitation and Recovery, and Assistant Scientific Director at Lawson, NFA seeks to stop the cycle between hospital admissions and homelessness by providing timely and accessible supports to patients who would otherwise be discharged into homelessness. It brings housing and financial supports into the health-care system, starting as soon as upon admission, to assist in finding appropriate housing and supports or avoiding a potential eviction.
Several departments at London Health Sciences Centre (LHSC) and St. Joseph’s Health Care London collaborate with staff from the City of London, Canadian Mental Health Association (CMHA) Elgin-Middlesex, Youth Opportunities Unlimited (YOU), Salvation Army’s Housing Stability Bank and Ontario Works in the City of London to provide direct, on-site (or virtual) support for patients at risk of homelessness.
Patients discharged from hospital to homelessness in Canada face many challenges that make recovery more difficult. They often experience higher readmission rates and emergency department visits. This is particularly concerning for youth, who have been found to be the fastest growing segment of the homeless population.
NFA was initially tested with strong success for mental health patients across the city and the second version of the project was extended to medical units at LHSC’s University and Victoria Hospitals.
PROJECT 1: Collaboration to Address Homelessness - Health, Housing and Income (H2I)
This research study will evaluate the City of London’s Coordinated Access Outreach program at hospital sites. A Coordinated Access Outreach worker will support individuals at risk of homelessness to maintain or obtain housing. Ontario Works will assist with the provision of income and employment supports and the Salvation Army Housing Stability Bank may be accessed for needed financial resources to secure or maintain housing.
Over two years, 106 participants will be interviewed in hospital and again six months post-discharge. Focus groups with participants, health care providers and community partners will provide further insight into the effectiveness of NFA. This project is funded by the Canada Mortgage and Housing Corporation (CMHC)’s National Housing Strategy.
PROJECT 2: Preventing discharge to No Fixed Address – Youth (NFA-Y)
This research study will customize, implement and evaluate the NFA strategy for vulnerable youth agSwitch to plain text editores 16-24. The unique health and housing needs of youth at-risk will be explored by streamlining housing and financial support into a coordinated system of care, with additional support provided by Youth Opportunities Unlimited and Children’s Aid Society London and Middlesex.
Over 3-4 years, data to be collected from 93 youth at three time points. Focus groups with youth participants, health care providers, and community agency partners will help enhance the NFA strategy to meet the unique needs of youth. This project is funded by the National Centres of Excellence (NCE) Making the Shift (MtS) Youth Social Innovation Lab.
Media Coverage
- Could this project keep discharged hospital patients from homelessness? - London Free Press
- London, Ont., expands work to prevent homelessness after hospital stays - Global News
- London expands strategy to curb homelessness after hospital stays - Blackburn News
- What happens to people who are discharged from hospital if they have nowhere to go? - CBC London
Learn more about No Fixed Address
London experts will discuss the health effects of vaping at community event
LONDON, ON – In 2019, a spate of vaping-related lung injuries occurred across North America, dominating headlines. While one in four high school students have tried vaping in the past 30 days, the full extent of the health effects are still being studied by clinicians and researchers.
On March 10, 2020, Lawson Health Research Institute and Western University’s Schulich School of Medicine & Dentistry are inviting the community to hear the latest about vaping research and policy from a panel of experts and to join the conversation about the health effects of vaping.
Lawson and Schulich Medicine & Dentistry experts are at the forefront of research into the effects of vaping and are actively contributing to the scientific and clinical knowledge around vaping-related lung injury.
This community event includes a series of small presentations followed by a panel discussion.
Panelists include:
- Dr. Karen Bosma was part of the team that published the first reported case of vaping-related lung injury in Canada. She is a Critical Care Specialist at London Health Sciences Centre, an Associate Scientist at Lawson Health Research Institute and an Associate Professor at Schulich Medicine & Dentistry.
- Dr. Constance Mackenzie was part of the team that published the first reported case of vaping-related lung injury in Canada. She is an Assistant Professor at Schulich Medicine & Dentistry, a Respirologist and Toxicologist at St. Joseph’s Health Care London and the Assistant Medical Director at Ontario/Manitoba/Nunavut Poison Centre.
- Dr. Grace Parraga is a Professor at Schulich Medicine & Dentistry, Western University, Tier 1 Canada Research Chair in Lung Imaging, and a Scientist at Robarts Research Institute.
- Suraj Paul, Aliana Manji, and Morgan Seabrook are high school students who are part of the Human Environments Analysis Laboratory Youth Advisory Council (HEALYAC) at Western. This group of young people used existing research and their own personal experience to inform a position paper on vaping that called for strict marketing rules and new safeguards on the online purchase of vaping products for anyone under the age of 19.
- Carly Weeks is a Health Reporter for The Globe and Mail who has extensively reported on the cases of vaping-related injury across North America. She’ll bring background and will moderate the panel discussion.
Event Details:
- Date: Tuesday, March 10, 2020, 7:00 – 8:30 p.m. (doors open at 6 p.m.)
- Location: Lecture Theatre, Museum London, London, Ontario
The event is completely full to capacity. Members of the media are welcome to attend the panel discussion, but must contact Crystal Mackay to confirm attendance and to request interviews.
-30-
Western delivers an academic experience second to none. Since 1878, The Western Experience has combined academic excellence with life-long opportunities for intellectual, social and cultural growth in order to better serve our communities. Our research excellence expands knowledge and drives discovery with real-world application. Western attracts individuals with a broad worldview, seeking to study, influence and lead in the international community.
The Schulich School of Medicine & Dentistry at Western University is one of Canada’s preeminent medical and dental schools. Established in 1881, it was one of the founding schools of Western University and is known for being the birthplace of family medicine in Canada. For more than 130 years, the School has demonstrated a commitment to academic excellence and a passion for scientific discovery.
Lawson Health Research Institute is one of Canada’s top hospital-based research institutes, tackling the most pressing challenges in health care. As the research institute of London Health Sciences Centre and St. Joseph’s Health Care London, our innovation happens where care is delivered. Lawson research teams are at the leading-edge of science with the goal of improving health and the delivery of care for patients. Working in partnership with Western University, our researchers are encouraged to pursue their curiosity, collaborate often and share their discoveries widely. Research conducted through Lawson makes a difference in the lives of patients, families and communities around the world. To learn more, visit www.lawsonresearch.ca.
Senior Media Relations Consultant
Communications & Public Engagement
T: 519-685-8500 ext. 73502
Celine.zadorsky@lhsc.on.ca
London Health Research Day 2016
You are invited to London Health Research Day, presented in partnership by Lawson Health Research Institute and the Schulich School of Medicine & Dentistry.
Showcasing 400 poster and platform presentations from top graduate trainees, this premier research event is your opportunity to learn about health research being conducted across the city of London.
Dr. Peter Libby, 2016 keynote speaker, will be presenting “Inflammation and atherosclerosis: A translational tale” as part of The Lucille & Norton Wolf Health Research Lecture Series. Dr. Libby is a cardiovascular specialist at Brigham and Women's Hospital in Boston, Massachusetts, and holds the Mallinckrodt Professorship of Medicine at Harvard Medical School. His current major research focus is the role of inflammation in vascular diseases.
Guest registration is required for the lunchtime keynote speaker at 11:30 a.m. and the wine and cheese awards reception at 5:30 p.m. The day also features workshops with industry leaders. Register today!
Date: Tuesday, March 29, 2016
Time: 7:30 a.m. - 6:30 p.m. View the full event schedule.
Location: The DoubleTree by Hilton London Ontario and London Convention Centre. See location details.
London Health Research Day 2017
You are invited to London Health Research Day, presented in partnership by Lawson Health Research Institute and the Schulich School of Medicine & Dentistry. Showcasing hundreds of poster and platform presentations from top graduate trainees, this premier research event is your opportunity to learn about health research being conducted in London.
Guest registration is required for the lunchtime keynote speaker at 11:45 a.m. and the networking and awards reception at 5:30 p.m.
Register today.
Dr. Paul Thagard, 2017 keynote speaker, will be presenting “Explaining Mental Illness” as part of The Lucille & Norton Wolf Health Research Lecture Series.
Dr. Thagard is Professor Emeritus of Philosophy at the University of Waterloo, where he founded the Cognitive Science Program. He has written many papers and books, including The Cognitive Science of Science (MIT Press, 2012) and How Scientists Explain Disease (Princeton University Press, 1999). His main research areas are philosophy of science and medicine, cognitive science and philosophy of the mind.
LHRD Poster Passports and Prizes
All guests and participants will receive a LHRD poster passport card. Throughout the day you can visit different posters and engage with presenters to fill up your passport for a chance to win a prize. Draws for both the morning and afternoon sessions will take place at the networking and awards reception – attend to find out if you’re a winner!
EVENT DETAILS
Date: Tuesday, March 28, 2017
Time: 7:30 a.m. to 6:30 p.m. View the full event schedule.
Location: London Convention Centre. See location map and transportation/parking details.
Registration is required
London Health Research Day 2018
Register today for London Health Research Day (LHRD) and experience the largest research-focused activity in Southwestern Ontario.
With hundreds of presentations from top learners, LHRD is your opportunity to learn about health research being conducted in the city of London. Dr. Janet Smylie, an international leader in the field of Indigenous health and health research, is this year’s keynote speaker as part of The Lucille & Norton Wolf Health Research Lecture Series.
Dr. Smylie will also join a group of local and national researchers as part of a new event - Exchange: A London Health Research Day Forum on Diversity and Inclusivity.
Exchange: A London Health Research Day Forum on Diversity and Inclusivity
Exchange aims to foster conversations around equity, diversity and inclusivity in the careers of health researchers, including gender, and how we can work together to identify and implement solutions.
- Date: Wednesday, May 9, 2018
- Time: 6:00 - 9:00 p.m.
- Location: North Campus Building, Western University. See campus map.
- Registration is required.
The evening’s presenters include:
- Dr. Janet Smylie – An international leader in the field of Indigenous health and health research
- Dr. Greta Bauer – A scientist at Western University’s Schulich School of Medicine & Dentistry with a special interest in LGBTQ health
- Dr. Alysha Croker – Current manager of the Canada Excellence Research Chairs (CERC) and the Canada First Research Excellence Fund (CFREF) programs at the Tri-agency Institutional Program Secretariat, and previous lead on the development of the Canadian Institutes of Health Research’s (CIHR’s) Equity Strategy
- Shantal Feltham – Founder of Stiris Research, a London-based North American clinical trial management company
- Learners from Schulich Medicine & Dentistry, training in labs at Western and Lawson Health Research Institute
London Health Research Day 2018
- Date: Thursday, May 10, 2018
- Time: Registration begins at 7:30 a.m. View the full event schedule.
- Location: London Convention Centre. See location map and transportation/parking details.
- Guest registration is required for the lunchtime keynote speaker and the networking and awards reception.
London Health Research Day is presented in partnership by Lawson Health Research Institute and the Schulich School of Medicine & Dentistry.
London Health Research Day 2020
EVENT CANCELLED
In alignment with recommendations from the Middlesex-London Health Unit, our local hospitals and the provincial and federal governments, the partner organizations for London Health Research Day have decided to cancel this year’s event scheduled for Tuesday, May 5, 2020 at RBC Place London. This is due to the changing nature and spread of COVID-19, and in an effort to minimize the potential risk to researchers, staff and learners as well as community members.
This is one of many events in the coming weeks that these partner organizations have to postpone or cancel. While it is disappointing to make this change, it is important that we minimize the risk for our people and the greater community.
London Health Research Day will return in 2021. Thank you for your understanding.
Dr. Susanne Schmid
Chair, London Health Research Day Academic Committee
London Health Research Day 2021 - VIRTUAL
Discover London's health research community by joining learners and researchers virtually at the 2021 London Health Research Day scheduled for May 11.
London Health Research Day is an opportunity to learn about research happening in labs and clinics across the city while engaging in scientific discussion.
LHRD 2021 is going virtual, offering a wide range of workshops, a keynote lecture, and several days dedicated to research presentations.
Registration
Register now for an opportunity to review research presentations or to take part in the workshops or keynote lecture. Due to a limited attendance capacity, pre-registration is required. Don’t miss your opportunity to take part in LHRD 2021!
Please note: If you are a poster presenter, you will receive an email from Janelle Pritchard with instruction on your pre-registration. Please follow directions as outlined in her communication for registration and to sign up for the sessions taking place on May 11.
Registration deadline is May 5, 2021.
Event Day Agenda
View the full event schedule here.
Morning Workshops
10:15 – 11:45 a.m. – Workshop options:
Science to Business Network Presents (S2BN): Insights into Industry- Exploring Careers for Graduate Students
Hosted by S2BN London, this workshop features a panel of esteemed industry professionals who will discuss their unique career journeys, the skills and knowledge needed to excel in their positions, and steps graduate students can take to enter these industries and succeed. This 90-min session will consist of a panel discussion moderated by Dr. Bruce Seet, Director of Medical Affairs at Sanofi Pasteur and President of S2BN. The panel discussion will be followed by an opportunity to network and interact with the panelists.
Reforming Equity, Diversity and Inclusion in Academic and Professional Health Settings: Fundamentals, Gaps and Accountability
In this 90-minute interactive workshop, learn directly from advisors, experts, and trainees on how to adopt equity, diversity, and inclusion practices in academic and health research health settings.
The Lucille & Norton Wolf Health Research Lecture Series – featuring Andrew Au
12:00 – 1:30 p.m.
Afternoon Workshops
1:30 – 3:30 p.m. - Workshop options:
Knowledge Mobilization via The Conversation Canada
The Conversation Canada is a daily independent online publication, delivering analysis and explanatory journalism from the academic and research community directly to the public. Deputy Editor Hannah Hoag and Editor-in-Chief Scott White will explain the mission of The Conversation Canada, offer some background on how it helps academics with knowledge mobilization and give some tips on how to pitch a really great story idea. This is an interactive workshop where participants are encouraged to bring story ideas to discuss.
Interview Skills/Strategies for Academic and Non-academic Positions
This workshop consists of two concurrent sessions focused on interview skills/strategies needed for academic and non-academic job positions. During the workshop, a panel of speakers who have vast proficiency in the recruitment process will share their experiences with attendees.
Academic Program for Learners
Abstract submissions:
LHRD) showcases the incredible work done by learners — graduate students, trainees, clinical fellows and postdoctoral scholars. Abstract submission is now closed.
Go to the LHRD website for more information for participants.
The Lucille & Norton Wolf London Health Research Day Trainee Publication Awards:
Thanks to the personal generosity of Lucille and Norton Wolf, we are pleased to issue a call for The Lucille & Norton Wolf London Health Research Day Trainee Publication Awards.
Learn more about the eligibility criteria and how to apply.
London Health Research Day is presented in partnership by Lawson Health Research Institute and the Schulich School of Medicine & Dentistry.
London Health Research Day 2024 highlights innovation and spotlights the future of AI in health care
Over 400 learners, faculty and researchers from across London Health Sciences Centre (LHSC), St. Joseph’s Health Care London (St. Joseph’s) and Western University gathered for London Health Research Day (LHRD) on May 7, 2024.
LHRD is one of southwestern Ontario’s largest cross-disciplinary health research conferences, and is presented in partnership by Lawson Health Research Institute (the research institute of LHSC and St. Joseph’s) and Western’s Schulich School of Medicine & Dentistry and Faculty of Health Sciences. It is an opportunity for students to share innovative research on a wide variety of health topics, practice science communication, network, and learn from an insightful keynote presentation and informative workshops.
“There is an amazing diversity of health research being conducted in London, Ontario right now, all represented at this event,” says Dr. David Hill, Interim Research Executive and Scientific Director for London Health Sciences Centre (LHSC). “Looking at all these presentations, the future of health research is bright.”
More than 420 guests, 340 poster presenters, 50 volunteer judges and 24 symposia speakers registered to attend the event held at Western University.
“An event like this, focused on health research by learners, provides an outstanding opportunity for our trainees to showcase their research and network with peers and leaders in the field,” says Susanne Schmid, Vice Dean of Basic Medical Sciences at Schulich Medicine & Dentistry. “As one of the largest health research gatherings in our city, London Health Research Day not only highlights the amazing work being done at Western, LHSC and St. Joseph’s, but also underscores the powerful collaborations that drive our success.”
Dr. Lisa Porter, Vice President, Research and Scientific Director at St. Joseph’s, was also on-hand to speak with presenters and learn more about ongoing research.
“I am so proud of the great research happening in London,” says Dr. Porter. “This event is a wonderful opportunity to explore the fabulous research and see what the future holds for health care.”
The event was preceded on May 6 with a public lecture by Dr. Mark Daley, Chief AI Officer at Western University, who addressed how artificial intelligence (AI) has the potential to change the future of health research and the lives of Canadians. The potential of AI to address ongoing challenges in health care, was echoed by keynote speaker Dr. Laura Rosella, Canada Research Chair in Population Health Analytics at the University of Toronto.
The impact of technology on health research was already visible in many of the projects presented by learners, highlighting the rapid advancement of health research in London, Ontario.
Communications Consultant & External Relations
Lawson Health Research Institute
T: 519-685-8500 ext. ext. 64059
C: 226-919-4748
@email
London Health Research Day highlights importance of science communication
Science communication is a key element of modern health research. From presenting at conferences to sharing research findings with the public, it’s a crucial skill for young researchers to develop.
London Health Research Day (LHRD) provides the opportunity for hundreds of graduate students, trainees, clinical fellows and postdoctoral scholars to practice science communication through the delivery of poster and oral presentations. At the eighth annual LHRD on April 30, more than 400 learners participated from across Lawson Health Research Institute and Western University’s Schulich School of Medicine & Dentistry and Faculty of Health Sciences.
Above: Participants engaging in poster presentations at LHRD 2019
“I love that LHRD brings trainees of all disciplines together to present our work, allowing us to become familiar with the research that is being performed outside of our respective areas. Being recognized with an award for my platform talk made the day even more rewarding,” said Shelby Oke, a PhD candidate working with Dr. Dan Hardy, Scientist at Lawson and Associate Professor at Schulich Medicine & Dentistry. Oke is conducting research to determine how maternal insults during pregnancy, such as a low protein diet, influence fetal growth and development.
This year’s LHRD keynote speaker, Timothy Caulfield, highlighted how science communication is particularly important in the age of misinformation. Caulfield, author of the bestseller Is Gwyneth Paltrow Wrong About Everything ?: When Celebrity Culture and Science Clash and host of the documentary TV series A User’s Guide to Cheating Death, presented as part of The Lucille & Norton Wolf Health Research Lecture Series. His talk, titled “Science vs. Celebrity: A Battle We Must Win,” focused on the important role scientists play in the battle against pseudoscience.
“London Health Research Day is an amazing event. It brings together a unique, engaged and highly interdisciplinary community,” noted Caulfield. “Great energy. Great discussion. Great research. What more do you need? It was an honour to be involved."
Above: Timothy Caulfield
Caulfield also participated in a panel discussion on science communication alongside local science communicators Ramina Adam, Dr. Lorelei Lingard, Dr. David Palma and Dr. Matthew Teeter. The panel was moderated by Carly Weeks, Health Reporter at The Globe and Mail, and focused on the importance of communicating science effectively and responsibly.
“The panel created an incredible opportunity to discuss science communication. I think that it was a great starting point to encourage trainees to get more involved in outreach efforts,” said Ramina Adam, a PhD candidate at Schulich Medicine & Dentistry. “Having that in-depth discussion about the importance of science outreach was a great follow-up to Timothy Caulfield’s keynote presentation and very encouraging for trainees who are passionate about the topic.”
Above: Ramina Adam shares her perspectives as part of the LHRD panel discussion on science communication.
From the presentation of research projects to the panel discussion, LHRD 2019 was an engaging day of networking and professional development that highlighted the scope of health science in London, Ontario.
For a full list of this year’s award recipients and to see the photo gallery, please visit the LHRD website.
London holds 8th place ranking in Canada's Top 40 for hospital-based research
Lawson Health Research Institute is again ranked eighth in the country according to the 2020 edition of “Canada’s Top 40 Research Hospitals List” by Re$earch Infosource. This strong national position has been maintained by Lawson for the past seven consecutive years and keeps the Institute within the top five in Ontario.
Lawson, the research institute of London Health Sciences Centre and St. Joseph’s Health Care London, has also maintained the top ranking for research intensity among the large tier institutions with $600,000 of research spending per researcher.
“Now, more than ever, people are understanding the critical importance of hospital-based research and its impact on health care,” says Dr. David Hill, Lawson Scientific Director and VP, Research for London Health Sciences Centre and St. Joseph’s Health Care London.
“We have remarkable people right here in London working on solutions for health challenges that have a worldwide impact. Their knowledge, creativity and dedication never fail to astound.”
The top 40 list analyzes hospital-based research institutes from across the country on several metrics, including total research income from the previous fiscal year. The ranking looks at funds received from all sources, including both internal and external, to support research at the organization. According to the report, Lawson received $118,796 million in research income in 2019. Despite representing a 4.0 per cent drop from the previous fiscal year, Lawson has maintained its rankings on the national list.
Hospital-based researchers belong to a health system at the forefront of the COVID-19 pandemic. With close proximity to patients and access to samples, they have mobilized to address COVID-19. Many Lawson research teams are implementing pre-clinical, clinical observational and clinical trial studies to prevent or soften the worst effects for patients with COVID-19. They are also studying the long-term and mental health impacts related to the pandemic.
“The COVID-19 pandemic is proving to be one of the most pressing health challenges of our time,” notes Dr. Hill. “Lawson excels in rapid response research and is uniquely positioned to tackle health problems from within hospital walls.”
Quick summary of Lawson's ranking
-
Rank in Top 40 Research Hospitals 2020: 8 (same as 2019)
-
FY2019 research spending: $118,776 million
-
FY2018 research spending: $123,790 million
-
Percentage change 2018-2019: -4.0%
-
Research intensity: $600,000 per researcher
-
Research intensity - percentage of total hospital spending: 7.0%
London Imaging Discovery Day 2017
Tuesday June 27, 2017 will mark the 12th annual London Imaging Discovery Day, an event showcasing the best and brightest residents, fellows, and scientists Schulich Medicine & Dentistry, Medical Imaging has to offer. This year, the venue will be at The Sumner Auditorium, London Health Sciences Centre, Victoria Hospital.
The objectives of the event are as follows:
- To provide a forum for trainees, residents, and graduate students
- To enable residents and graduate students to learn and experience presenting to an audience
- To facilitate a congregation of knowledge with an extensive poster exhibition of research with the department
- To invite Keynote speakers on education and research to showcase their expertise
- To further develop the CANMEDS roles of Communicator and Collaborator through the focus on leadership development and relationship building
The event is free, open to all, and is a great opportunity to review the research at hand, enjoy refreshments and good company, and celebrate our successes over the past year. Our Keynote Speaker this year will be Dr. Chris Watling, Associate Dean , Postgraduate Medical Education, Schulich School of Medicine & Dentistry, Western University. He will be speaking about Building the Foundation: Observation and Feedback in CBME.
London ranks in the top 10 for hospital-based research
Lawson Health Research Institute is ranked eighth in the country according to the 2019 edition of “Canada’s Top 40 Research Hospitals List” by Re$earch Infosource. This strong national position has been maintained by Lawson for the past six years and also keeps the institute within the top five in Ontario.
The results
The research institute of London Health Sciences Centre and St. Joseph’s Health Care London (St. Joseph’s), Lawson has also maintained the top ranking for research intensity among the large tier institutions with $612,800 of research spending per researcher.
“As a hospital-based research institute, our innovation happens where care is delivered,” says Dr. David Hill, Lawson Scientific Director. “Every day, teams of researchers are working directly with clinicians and patients to improve treatments or create entirely new ones. They also find innovative methods of delivering services that drive efficiency and reduce costs.”
Dr. David Hill, Lawson Scientific Director.
The top 40 list analyzes hospital-based research institutes from across the country on several metrics, including total research income from the previous fiscal year. The ranking looks at funds received from all sources, including both internal and external, to support research at the organization. According to the report, Lawson received $123,790 million in research income in 2018, which represents 0.4 per cent in growth from the previous fiscal year.
“We are known across the country and around the world for our high level of research activity and success, despite our size. London punches well above our weight when it comes to health research,” adds Dr. Hill.
“Our position as a leading research institute is the foundation for brilliant research and worldwide partnerships tackling the most pressing challenges in health care.”
What does this mean for London, Ontario?
There are millions of dollars every year coming in London from elsewhere in Canada and in the world. Approximately 60 per cent of that is spent on jobs. Lawson employs over 2,000 people in hospital-based research. This is a major source of quality employment for Londoners and people in the surrounding region. Dr. Hill notes that this is one of the real benefits of having a strong biomedical industry associated with the city.
“Another real benefit of having research directly in the hospitals is that our researchers focus on gaining knowledge that advances our ability to treat patients and find solutions to wicked problems that have been around for a long time.”
For example, Lawson researchers have been tackling the issue of homelessness from within hospital walls. The No Fixed Address (NFA) strategy reaches and supports patients during the crucial transitional period when they are being discharged from the hospital and re-integrated into the community. Learn more about this successful research initiative.
Dr. Cheryl Forchuk, Lawson Scientist leading the NFA strategy in London hospitals.
How are we adapting to the current funding environment?
While federal funding for research in Canada is slowly starting to increase, this sector experienced over a decade of decreasing funding that placed the country far behind other nations in terms of investing in health research.
“We have become better at what we do in competing for grants and other funding sources, in particular from the government,” explains Dr. Hill.
Also, “Lawson has been diversifying our sources of funding. We’ve have engaged in more partnerships with industry and joint research and development projects with companies. Not only does that have the advantage of providing additional resources, but also is often a more practical way of directly delivering our knowledge into salable products”
Strong partnerships
This year, Re$earch Infosource is showcasing “Building Bridges: Pathways to Building Research Capacity and Discovery through Collaboration.” Health researchers in London have collaborations across many sectors that result in big impacts for the people in this region and beyond.
As just one example, a group of scientists from Lawson, Brescia University College and Schulich School of Medicine & Dentistry at Western University provide academic support to London’s Fermented Foods Project that brings together industry partners, the agricultural sector, academic and health institutions, the City of London and the London Economic Development Corporation.
The goals of this group, funded by the Weston Family Microbiome Initiative, are to support new product development and batch production, enhance customer confidence, quantify health benefits and establish a competitive advantage.
Dr. Gregor Reid, left, is one of the researchers for London's Fermented Foods Project.
London ranks in top ten of Canada’s research hospitals
MEDIA RELEASE
For immediate release
January 18th, 2022
LONDON, ON – Lawson Health Research Institute has ranked eighth in the country for the 2021 edition of Canada’s Top 40 Research Hospitals List by Re$earch Infosource. This is the eighth consecutive year that Lawson has maintained this strong national position, which puts the institute within the top five in Ontario.
Lawson, the research institute of London Health Sciences Centre (LHSC) and St. Joseph’s Health Care London, has also maintained the top ranking for research intensity among the large tier institutions with a little more than $600,000 of research spending per researcher.
“This is a validation of the extensive support from LHSC and St. Joseph’s, our hospital foundations, Western University and our staff and physicians,” says Lawson’s Scientific Director Dr. David Hill. “These strong partnerships make the hospital environment in London a nationally recognized centre of discovery and knowledge translation.”
Hospital-based researchers belong to a health system at the forefront of the ongoing COVID-19 pandemic. With close proximity to patients and access to samples, they have mobilized to address COVID-19 in many different ways, and are making a difference around the world when it comes to advances and discoveries.
“The Province of Ontario designated health research as an essential service early in the pandemic,” explains Dr. Hill. “They understood that only science can get us through this, be it through vaccine development, surveillance and testing, evaluating new drugs to help patients in ICU survive, or studying the long-term health impacts. We have made substantial contributions of new knowledge through Lawson.”
The top 40 list analyzes hospital-based research institutes from across the country on several metrics, including total research income from the previous fiscal year. According to the report, Lawson received $121,888 million in research income in 2021.The ranking looks at funds received from all sources, including both internal and external, to support research at LHSC and St. Joseph’s.
Quick summary of Lawson’s ranking
- Rank in Top 40 Research Hospitals 2021: 8 (same as 2020)
- FY2020 research spending: $121,888 million
- Percentage change 2019-2020: 2.6%
- Research intensity: $618,700 thousand per researcher
- Research intensity - percentage of total hospital spending: 7.0%
-30-
About Lawson Health Research Institute: Lawson Health Research Institute is one of Canada’s top hospital-based research institutes, tackling the most pressing challenges in health care. As the research institute of London Health Sciences Centre and St. Joseph’s Health Care London, our innovation happens where care is delivered. Lawson research teams are at the leading-edge of science with the goal of improving health and the delivery of care for patients. Working in partnership with Western University, our researchers are encouraged to pursue their curiosity, collaborate often and share their discoveries widely. Research conducted through Lawson makes a difference in the lives of patients, families and communities around the world. To learn more, visit www.lawsonresearch.ca.
For more information, please contact:
Celine Zadorsky
Communications & External Relations
Lawson Health Research Institute
T: 519-685-8500 ext. 75664
C: 519-619-3872
@email
www.lawsonresearch.ca/news-events
Senior Media Relations Consultant
Communications & Public Engagement
T: 519-685-8500 ext. 73502
Celine.zadorsky@lhsc.on.ca
London researchers adapt MRI technology to image salt within the kidneys
LONDON, ON – In a newly published study, scientists at Lawson Health Research Institute have adapted PET/MRI technology to accurately image salt within the kidneys of patients with kidney disease.
“Salt is very difficult to image in an MRI because the signal is much weaker than water,” explains Dr. Christopher McIntyre, Lawson Scientist and Nephrologist at London Health Sciences Centre (LHSC). “We wanted to find a way to look at the fundamental role of the kidney in getting rid of salt and water by using a functional MRI.”
Imaging salt within the kidneys has never been accurately accomplished in patients with kidney disease, but Dr. McIntyre and his team developed new technology and software that was adaptable to a PET/MRI machine at St. Joseph’s Health Care London. The new technology allowed the machine to image salt and water levels within the kidney.
“Salt within the kidneys have only been imaged in pre-clinical models, and low weight, healthy volunteers,” says Dr. McIntyre. “Since the kidney is further away from the MRI coils, and the organ moves when a person breathes, it is definitely very hard to image.”
This was the first study to use MRI to look at salt within the kidneys with a wide range of participant with different body types (10 healthy volunteers), as well as patients with kidney disease (five patients). The research team also imaged patients who had a combination of kidney disease and heart failure, because it is especially important for those patients specifically to be able to release salt and water as part of their treatments.
Currently clinicians rely on kidney biopsies to measure salt levels, but Dr. McIntyre says that method isn’t as accurate or effective as it could be.
“The problem is that the biopsies are painful, they have risks, and because it is a small sample of the kidney, we don’t get an accurate perspective of the kidney as a whole,” Dr. McIntyre explains.
The study, which is published in Radiology has now opened the door to new possibilities when it comes to clinical care for patients with kidney disease.
“Salt is very toxic in patients with kidney failure,” adds Dr. McIntyre. “This will now allow us to diagnose and manage both chronic and acute kidney disease. It is a significant step forward.”
The next steps for the research team will be to compare salt MRI’s to biopsies, while also examining potential new therapy developments.
“We are hoping we will have a higher degree of certainty moving forward to predict what will happen within the kidneys of these patients, with the possibility of using new targeted and effective treatments in the future,” notes Dr. McIntyre.
Lawson Health Research Institute is one of Canada’s top hospital-based research institutes, tackling the most pressing challenges in health care. As the research institute of London Health Sciences Centre and St. Joseph’s Health Care London, our innovation happens where care is delivered. Lawson research teams are at the leading-edge of science with the goal of improving health and the delivery of care for patients. Working in partnership with Western University, our researchers are encouraged to pursue their curiosity, collaborate often and share their discoveries widely. Research conducted through Lawson makes a difference in the lives of patients, families and communities around the world. To learn more, visit www.lawsonresearch.ca.
Senior Media Relations Consultant
Communications & Public Engagement
T: 519-685-8500 ext. 73502
Celine.zadorsky@lhsc.on.ca
London researchers collaborating on national dementia prevention program
LONDON, ON - Researchers at Lawson Health Research Institute are collaborating with Canada’s largest dementia research initiative, the Canadian Consortium on Neurodegeneration in Aging (CCNA), to study an innovative online program that offers older adults the opportunity to increase their knowledge of dementia and improve lifestyle risk factors. The program, Brain Health PRO (BHPro), offers interactive digital educational modules to empower older adults to improve their physical and mental health, and modify their risk factors for dementia.
“Using the BHPro modules participants will learn how to improve their physical and mental health and reduce their risk of cognitive impairment. It is particularly novel with the education modules being delivered remotely,” explains Dr. Michael Borrie, Scientist at Lawson and Medical Director for the Aging Brain and Memory Clinic at Parkwood Institute.
The bilingual program focuses on seven different modifiable dementia risk domains: exercise, nutrition, sleep, psychological and social health, cognitive engagement, heart health, and vision and hearing. For each, the program includes 10-minute educational videos, as well as interactive activities for users to complete. Participants will also be sent portable EEG headsets to measure their brain activity during sleep, and accelerometers to track their physical activity. With the rise of dementia anticipated to reach nearly one million Canadians over the next 12 years, dementia prevention is becoming an increasingly urgent national health priority.
“The launch of BHPro is part of a significant research effort to find concrete means of preventing dementia, with the ultimate goal of having tremendous benefits for the aging experience,” says Dr. Howard Chertkow, Scientific Director of the CCNA and Director of the Kimel Family Centre for Brain Health and Wellness at Baycrest.
“Alzheimer Society of Canada (ASC) is proud to support the launch of the BHPro through the CAN-THUMBS UP program,” adds Dr. Saskia Sivananthan, ASC’s Chief Research & KTE Officer.
BHPro is funded by the Canadian Institutes of Health Research and the ASC, and was created through the Canadian Therapeutic Platform Trial for Multidomain Interventions to Prevent Dementia (CAN-THUMBS UP) program, which is part of the CCNA. The study will support 350 older adults across Canada who have at least one risk factor for dementia, including up to 60 participants through Lawson, with the goal of seeing participants’ dementia risk reduced throughout the year-long study. Please note, there is limited space for research participants. To learn more, please visit canthumbsup.ca
About CCNA
CCNA is the national component of the CIHR dementia research strategy, bringing together over 340 researchers across Canada to collaboratively investigate the diagnosis, treatment and prevention of dementia and other age-related neurodegenerative diseases. For more information, visit ccna-ccnv.ca
Lawson Health Research Institute is one of Canada’s top hospital-based research institutes, tackling the most pressing challenges in health care. As the research institute of London Health Sciences Centre and St. Joseph’s Health Care London, our innovation happens where care is delivered. Lawson research teams are at the leading-edge of science with the goal of improving health and the delivery of care for patients. Working in partnership with Western University, our researchers are encouraged to pursue their curiosity, collaborate often and share their discoveries widely. Research conducted through Lawson makes a difference in the lives of patients, families and communities around the world. To learn more, visit www.lawsonresearch.ca.
Communications Consultant & External Relations
Lawson Health Research Institute
T: 519-685-8500 ext. ext. 64059
C: 226-919-4748
@email