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From falls prevention to depression therapies, scientists at Lawson Health Research Institute are conducting important mental health studies. Held on Thursday, September 15, the 17^th Annual Mental Health Research Half Day at the Parkwood Institute Mental Health Program was a chance to share and celebrate this research.

The Mental Health Research Half Day featured poster and oral presentations, as well as the 12^th Annual Tony Cerenzia Research Lecture. Clinical, administrative and research staff attended to learn more about research happening at Parkwood Institute and the Southwest Centre for Forensic Mental Health Care, part of the St. Joseph’s Health Care London family.

“The Mental Health Research Half Day provides an opportunity for researchers at Parkwood Institute and the Southwest Centre for Forensic Mental Health Care to present their research findings to clinical and administrative staff,” said Dr. Richard O’Reilly, Director of Psychiatric Research at Parkwood Institute & Southwest Centre and a Scientist at Lawson. “It is important that all clinical staff, who may not be directly involved in research, know what studies are being conducted and their impact on patient care.”

The 12^th Annual Tony Cerenzia Research Lecture was delivered by Dr. Nathan Herrmann, Associate Scientist, Evaluative Clinical Sciences, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute and Head of the Division of Geriatric Psychiatry at Sunnybrook Health Sciences Centre. Dr. Herrmann delivered an engaging lecture titled “Managing Neuropsychiatric Symptoms in Dementia: An Evidence-Based Approach”.

Attendees were engaged not only by this highly informative lecture but also by the poster and oral presentations which covered a broad range of research topics. Presenters were also enthusiastic about  the day and the opportunities it provided.

“The Mental Health Research Half Day is a great event which provides networking opportunities here at Parkwood Institute. It allows staff from across St. Joseph’s to learn about different research happening across program areas,” said Erin Finley, an Occupational Therapist (OT) in Geriatric Psychology at Parkwood Institute.

Finley and her colleagues were one of seven poster presentations. Their research project, titled “Fall prevention initiative in geriatric psychiatry”, aimed to reduce the rate of falls with injury among patients with dementia in a behavioural health unit. Within an 18-bed unit, they were able to significantly reduce falls with injury with zero incidences in the last two months of their data collection period.

Researchers at Lawson Health Research Institute are the first in the world conducting a clinical trial to test a triple intervention aimed at treating Mild Cognitive Impairment (MCI) and delaying the onset of dementia. The Mobility, Exercise and Cognition (MEC) team will be incorporating physical exercises, cognitive training and vitamin D supplementation to determine the best treatment for improving mobility and cognition.

“We have learned the brain processes involved in motor-control - for example how a person walks - and cognition - for example how that person solves a problem - share similar locations and networks in the brain,” explains Dr. Manuel Montero Odasso, Lawson Scientist and Geriatrician at St. Joseph’s Health Care London. “Problems with mobility are connected to lowering function in the mind, and so can be a good indicator of future progression into dementia.”

Dr. Montero Odasso is also an Associate Professor in the departments of Medicine and Epidemiology and Biostatistics at the Schulich School of Medicine & Dentistry, Western University. 

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MCI is an intermediate stage between the expected cognitive decline of normal aging and the more serious decline of dementia. It can involve problems with memory, language, thinking and judgment. While many older individuals experience decline in both mobility and cognition, each are assessed and treated separately with no specific recommendations available for physicians.

The SYNERGIC Trial will combine physical exercises, cognitive training and vitamin D to test how these interventions work together to improve cognition in older adults at risk for dementia. The trial is targeting cognitive decline at the earliest stage, individuals with MCI, where interventions are more likely to have an effect and can be monitored.

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Dr. Montero Odasso explains that both physical and cognitive exercises have shown promising effects for maintaining cognition, while vitamin D deficiency is associated with cognitive decline. A key feature of this trial is that participants will receive individualized and progressive training.

“By delaying declines in cognition, we can improve a person’s quality of life. This research will help to support a more comprehensive preventative treatment with clinical guidelines for physicians whose patients are at risk of developing dementia,” states Dr. Montero Odasso. “Even more, each one year delay of progression to dementia in older individuals at risk has the opportunity to save billions of dollars for the Canadian health care system.”

Individuals over 60 years old with mild cognitive impairment without dementia are eligible for this clinical trial. Those interested in participating are encouraged to contact Research Coordinator Alanna Black at 519.685.4292 ext. 42179.

Participants will be asked to complete a routine of exercises and cognitive training three times a week for six months, with one final assessment at 12 months. The main site for the study is Parkwood Institute with physical exercises taking place at the Labatt Health Sciences Building at Western University, in Dr. Kevin Shoemaker’s Laboratory for Brain and Heart Health.

This study has been funded by the Canadian Consortium on Neurodegenerative in Aging (CCNA) which represents Canada-wide research aimed at enhancing the quality of life and services for individuals diagnosed with a neurodegenerative disease. The MEC team in London, led by Dr. Montero Odasso, includes expert researchers in the field of mobility who aim to develop common assessments for the interaction of cognition and mobility for older people to aid as a diagnostic tool for detecting dementia. 

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