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Dr. David Hill
D.Phil, FCAHS
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Research published in 2016 has identified a population of progenitor cells within the pancreas of mice and human that can give rise to new insulin-producing cells in vitro. These were not predominantly located in situ within the mature islets of Langerhans, but in small clusters of endocrine cells throughout the pancreas. The total number of progenitor cells was high in early life but declined with age. This suggests that progenitor cells with the potential to become insulin-producing cells exist throughout life and may represent a source of β-cell plasticity to reverse diabetes. As a step towards mobilizing these cells we have examined the ability of grafted bone marrow-derived stem cells to reverse diabetes in mice. Marrow-derived cells migrated to the diabetic pancreas and specifically activated progenitor beta cell proliferation.
We completed in 2016 a Pan-European clinical trial for the prevention of gestational diabetes. We are now following up both women and their offspring from the previous study to determine the extent to which interventions in pregnancy alter the development of subsequent type 2 diabetes in the mothers, and the development of obesity and glucose intolerance in the offspring.
Dr. David Hill holds the Lawson Professorship in Diabetes Research and is a Professor in the Departments of Medicine, Physiology & Pharmacology and Paediatrics, at Western University. He is Scientific Director of Lawson Health Research Institute and the Integrated Vice President, Research for London Health Sciences Centre and St. Joseph’s Health Care London.
Educated at the University of Nottingham and at Worcester College, University of Oxford, he has published over 200 scientific papers and maintains an active program in diabetes research and stem cell biology. He is a recipient of the CDA’s Frederick G. Banting Award, as well as of the Medal of the Society for Endocrinology from the UK. Dr. Hill was inducted as a fellow of the Canadian Academy of Health Sciences (CAHS) in 2011.
Dr. Hill’s research centres on the generation of new insulin producing beta cells in the pancreas as a strategy for the reversal of diabetes
Dr. Frank S. Prato
Over the last 30 years I have founded a research imaging program at Lawson that currently includes 23 Ph.Ds. and 7 MDs. The focus is to provide leading edge medical imaging technology to the patients of Southwestern Ontario, to citywide researchers and to foster what is needed for clinical trials. We have had a rich history including: first MRI in Canada (1982), first perfusion CT in the world (2000), first PET/CT in Canada (2002), first PET/MRI in Canada (2012).
In the last decade we have introduced PET technology to London including a medical cyclotron and radiochemistry facility that supplies Health Canada approved products to London, Toronto and Windsor. We are a hospital based research program and as such we have a stewardship responsibility to our patients to provide the best medical imaging facilities to guide their treatment and when they reach the limits of proven treatment methods they have the option to enroll in clinical trials that explore new treatment approaches.
Publications:
Scientific Record
- 6113 life time citations, h-index = 45 (Scopus)
- 10,624 life time citations, h-index = 58 (Google Scholar)
- 300+ peer-reviewed publications (222 papers)
- 700+ conference abstracts
- 184 invited presentations
- 67 graduate students and PDFs
- 14 patents and 4 spin-off companies
Dr. Gregor Reid
BSc Hons, PhD, MBA, ARM CCM, Dr HS, FCAHS, FRSC
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My career has mostly been spent studying how beneficial microbes, especially bacteria, contribute to the health of women and children.
The use of probiotics, as dried or food forms, is designed to help restore and maintain a healthy or homeostatic state. My focus has always been on translating science to human or other life forms (animals, honeybees, fish), though work on mechanisms was also rewarding. I was determined that breakthrough technologies and treatments should benefit everyone, particularly those most in need in developing countries whose access to healthcare and remedies is often limited.
I have been a strong advocate for empowering everyone who has come through out research group. Progress comes from the ideas and talents of these students, fellows, technicians and collaborators and it is our responsibility to mentor and encourage them.
Research areas: Microbiome and probiotics; Women's health; Environmental influences on health; probiotic effects on the urogenital tract, the gut, breast, heart and use of probiotics to detoxify environmental pollutants.
Publications:
Dr. Gregor Reid is a Distinguished Professor Emeritus of Western University, and Scientist in Human Microbiome and Probiotics at the Lawson Health Research Institute. He retired from laboratory research in 2020 and is no longer taking students.
Dr. Reid’s legacy comes from his focus on beneficial microbes, starting in 1982 when only 12 papers had been published on ‘probiotics’. As of February 2024, this number exceeds 47,000 papers by authors around the world. Dr. Reid's contribution cannot be understated. In 2001 and 2002, he chaired the United Nations - World Health Organization Expert Panel and Working Group on Probiotics that defined the modern term probiotics and set the standard for a field of science and commerce, the latter now exceeding $60 billion per annum.
Evidence for him being one of the world’s foremost experts on probiotics comes in many forms. Along with Canadian Urologist Dr. Andrew Bruce he developed novel probiotic therapies now used by several million people in over 35 countries. He helped acquire Canada’s largest ever donation for microbiology, $7 million for the endowed chair at Lawson. He has held 32 patents and published over 609 peer-reviewed publications in highly prestigious academic journals including Science, Lancet, JAMA, PNAS and various Nature journals. He has been highly sought for his lecturing skills, with over 650 talks in 54 countries. His Google Scholar H factor is 125 with over 61,000 citations as of February 2024. He was ranked the #3 microbiologist in Canada by research.com in 2022.
He has been President of the International Scientific Association for Probiotics and Prebiotics, the leading organization on the science of these areas. His recognitions include: recipient of the Hellmuth Prize, the highest research honour conferred by The University of Western Ontario; the Distinguished Alumni Award presented by New Zealand’s leading institution, Massey University; an Honorary Doctorate in Biology from Orebro University in Sweden; the highest honour of the Canadian Society for Microbiologists for Career Achievement; Western University’s highest honour as Distinguished Professor. He is a member of the Canadian Academy of Health Sciences and the Royal Society of Canada, the latter being an honour bestowed upon Canada’s distinguished scholars, artists and scientists, since the establishment of the society as Canada’s National Academy in 1883. His impact on Complementary and Alternative Medicine has been substantial, in Canada and beyond, illustrated by receipt of the prestigious Dr Rogers Prize.
The expansion of beneficial microbes to One Health illustrates the importance of pioneers like him, who so early on and long before the Human Microbiome Project, recognized the importance of these organisms. His commitment to stewardship and excellence in appropriately documenting probiotics and in helping to define fermented foods and prebiotics, and differentiate them from probiotics, is recognized the world over.
Dr. Reid was instrumental in the establishment of Western Heads East (WHE), an experiential learning program based out of Western University. The program, led by Bob Gough, launched probiotic yogurt in rural Tanzanian communities in 2004 to help address the malnutrition and HIV/AIDS crises in the continent. It was recognized by the awarding of the AUCC Scotiabank Prize for Internationalization in 2010. The program expanded beyond HIV recipients to reach over 260,000 beneficiaries in Uganda, Tanzania and Kenya. This was made possible by funding from the Canadian International Food Security Research Fund and the creation of a novel sachet by Yoba-for-Life, a Dutch not-for-profit foundation. The sachet, costing under $1, contains two bacterial strains that ferment up to 100L of probiotic-rich yogurt or cereal or fruit. Yoba-for-Life continues to bring sachets to Africa, and in 2024, The Gregor Reid Award for Outstanding Scholars in Developing Nations was established by ISAPP to encourage young researchers to translate probiotics into tangible benefits for their countries.
Dr. Reid's sphere of influence has widened through efforts to reduce the problem of honeybee colony collapse that endangers the world's food supply. The creation of a probiotic intervention to boost the insect's defenses and fight pathogens as well as offset the damage done by pesticides, has implications for beekeeping in North America and around the world. His final PhD student, Brendan Daisley is now pioneering this work at the University of Guelph.
Though officially retired, Professor Reid has published a book, “Probiotics: A story about hope,” which reached #1 on Amazon for women’s health, and he continues to support his successor, Dr. Jeremy Burton, and students doing outstanding work through the lab at St. Joseph’s Hospital.
Numerous collaborators around the world.
Read it here!
Dr. Jacobi Elliott
PhD
Dr. Elliott has focused on establishing a comprehensive program of research focused around geriatrics and the health care system.
As an Early Career Researcher (ECR), Dr. Elliott has been involved as Nominated Principal Applicant, co-Principal Applicant or co-Applicant on research funding from tri-council and community grants.
She has more than 35 published papers related to health systems research and patient/family engagement and has been recognized with multiple awards for her conference presentations.
Dr. Elliott is a Scientist with Lawson Research Institute and holds Adjunct Assistant Professor appointments at Western University (Faculty of Health Sciences) and the University of Waterloo (School of Public Health Sciences).
Currently, Dr. Elliott is the Director, Research & Strategy for the Regional Geriatric Program of Southwestern Ontario, hosted by St. Joseph's Health Care London.
Dr. Anurag Bhalla
BHSc (Honours), McMaster University
MD, Western University
FRCPC Internal Medicine and Respirology
MSc, Physiology and Phamacology, McMaster University
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Asthma, sputum cell counts, eosinophils.
Anurag Bhalla is an Assisstant Professor of Medicine in Department of Medicine, Division of Respirology at Western University and Staff Respirologist at St. Joseph's Healthcare and London Health Sciences Centre.
He completed his medical school and internal medicine residency at Western University followed by respirology residency at McMaster University. Subsequently, he completed airway disease clinical fellowship and MSc in physiology and pharmacology with Dr. Parameswaran Nair at McMaster University.
His clinical interest includes complex airway diseases, including asthma, COPD and bronchiectasis. His research interest includes severe asthma, eosinophil biology, asthma biologics and airway inflammometery.
Dr. Arlene MacDougall appointed Director of Research and Innovation for St. Joseph’s Mental Health Care
Dr. Arlene MacDougall has been appointed as Director of Research and Innovation for mental health care at St. Joseph’s Health Care London and Lawson Health Research Institute.
She will oversee and facilitate all mental health care research at both Parkwood Institute and Southwest Centre for Forensic Mental Health Care, working to develop strong local and global partnerships, engage patients and their caregivers in research activities, and foster trans-disciplinary approaches to research.
Her goal is to build on existing research strengths in mood disorders, suicide and smart technology. She also will look to develop research links between Mental Health and Parkwood Institute’s other major research programs, Cognitive Vitality and Brain Health, and Mobility and Activity.
Dr. MacDougall joined Lawson and the Department of Psychiatry at the Schulich School of Medicine & Dentistry, Western University in 2013 working with the Prevention and Early Intervention Program for Psychoses at London Health Sciences Centre. Last year she was cross appointed to the Department of Epidemiology and Biostatistics at Schulich.
“I come to this new role with a great deal of optimism, energy and enthusiasm. Parkwood Institute Research has a number of established strengths in the mental health care field as well as potential for new streams of research and innovation,” says Dr. MacDougall. “I look forward to working with researchers, staff, and patients and their supporters, as well as academic and community partners, to make Parkwood Institute a leading centre in Canada for mental health research.”
Parkwood Institute Research is a Lawson program that represents inter-disciplinary clinical research and focuses on the advancement of innovations and discoveries that directly improve patient care.
Dr. MacDougall will continue her own program of research, which includes recovery-oriented interventions for people with serious mental illness locally and in Africa. She is leading local studies on the use of mindfulness meditation and participatory video interventions to promote recovery among youth with early psychosis. She is also leading a project based in Kenya using social businesses and a low cost psychosocial rehabilitation toolkit to create meaningful employment, promote social inclusion and support the overall functioning and recovery of people with serious mental illness in low income settings.
Most recently she has been involved in developing and leading initiatives that use social innovation approaches to tackle complex mental health system challenges both locally and globally.
At Western, she is the Director of Global MINDS (Mental Health Incubator for Disruptive Solutions) @ Western, an educational and research initiative that supports students, faculty and community stakeholders to create solutions that will reduce the global burden of mental disorders. Global MINDS is focused on innovating for low and middle income countries and for marginalized communities in Canada. Another initiative, MINDS of London-Middlesex, is working with multiple local stakeholders to collaboratively establish a social innovation lab and use collective impact approaches that will lead to solutions that address complex challenges in the local mental health system.
Dr. MacDougall began her new role on February 1, 2017 and joins Drs. Michael Borrie and Tim Doherty as Joint/Acting Beryl and Richard Ivey Research Chair in Aging, Mental Health, Rehabilitation and Recovery. She also joins Lawson’s Research Executive Committee as Assistant Director (interim) for Parkwood Institute Research, Mental Health.
Dr. Clark Heard
Doctorate - Occupational Therapy - Temple University (Philadelphia, PA, USA)
Bachelor of Health Sciences - Occupational Therapy - McMaster University (Hamilton, ON, Canada)
- Focused on occupation, outcomes and the human experience of spirituality
Dr. Clark Heard is a staff occupational therapist at the Southwest Centre for Forensic Mental Health Care in St. Thomas, Ontario, Canada. Clark is also Adjunct Research Professor at the School of Occupational Therapy at Western University. A graduate of McMaster University (Hamilton, ON) and Temple University (Philadelphia, PA), Clark has a high volume of scholarly publication and has clinically precepted more than 125 occupational therapy students. A recipient of multiple teaching awards, Clark was nationally recognized by the Canadian Association of Occupational Therapists in 2015.Clark Has also been recognized with the Sister's of St. Joseph Award for Excellence in Care.
https://www.sjhc.london.on.ca/news-and-media/our-stories/unsung-heroes